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Cat. No.: HY-183266

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SR-A-174

SR-A-174 is a SARS-CoV-2 M^Pro inhibitor with an IC₅₀ of 0.060 μM. SR-A-174 has limited cell permeability and exhibits low activity in cells expressing M^Pro-eGFP, with a cellular IC₅₀ > 10 μM. SR-A-174 can be used in COVID-19-related research.

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Formule: C₁₉H₁₂Cl₄N₂O
Masse moléculaire:426.12

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-A-174 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

SR-A-174 potently inhibits purified SARS-CoV-2 M_Pro with an IC₅₀ of 60 nM^[1].
SR-A-174 has limited cellular permeability and activity in HEK293T cells expressing MPro-eGFP, with a cellular IC₅₀ > 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 426.12
Formule C₁₉H₁₂Cl₄N₂O
SMILES

O=C(N(C1=CC(C2=CC=CC(Cl)=C2)=CC=C1)C3=CC(Cl)=CN=C3)C(Cl)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Atla S, et al. Nicotine-Inspired, De Novo-Designed SARS-CoV-2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad. J Am Chem Soc. 2026 Apr 29;148(16):16985-16995. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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