STC314
STC314 is a histone-neutralizing agent. STC314 inhibits histone-mediated cytotoxicity, blocks histone-induced erythrocyte aggregation, reduces fragility, restores deformability and inhibits histone-induced aggregation and degranulation in human erythrocytes. STC314 reduces histone-mediated tissue damage, thrombocytopenia, anemia, and cell death, and improves survival in preclinical models. STC314 can be used for the research of sepsis, ischemia-reperfusion injury, and deep-vein thrombosis.
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- CAS No.: 401513-39-1
- Formule: C13H17Na7O32S7
- Masse moléculaire:1070.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
STC314 (Compound mCBS) (20-100 μg/mL; 1 h) potently inhibits histone-mediated cytotoxicity in HMEC-1 cells[1].
STC314 (12.5-400 μg/mL; 15 min-1 h) blocks histone-induced erythrocyte aggregation, reduces fragility, restores deformability and inhibits histone-induced aggregation and degranulation in human erythrocytes[1].
STC314 (mCBS) (0.9-500 μg/mL) stabilizes human NETs and does not displace histones from chicken RBC chromatin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human microvascular endothelial cell-1 (HMEC-1)
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Concentration:0-100 μg/mL
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Incubation Time:1 h
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Result:Inhibited histone-mediated HMEC-1 cytotoxicity.
STC314 (100 mg/kg; i.p.; single dose 2 hours post-histone injection) significantly reduces ongoing histone-induced multi-organ damage and cell death in male C57BL/6 mice when administered 2 hours after histone exposure[1].
STC314 (50 mg/kg; i.p.; four total doses: 5 minutes pre-clamp, 5 minutes post-clamp removal, 24 hours post-surgery, 48 hours post-surgery) significantly improves skin flap viability in male Wistar rats following ischemia-reperfusion injury[1].
STC314 (50 mg/kg; i.v.; single dose 5 minutes post-histone injection) almost completely prevents histone-induced deep vein thrombosis in male C57BL/6 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 5-6 weeks of age, histone-induced sepsis-like syndrome model)[1]
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Dosage:6.25 mg/kg; 25 mg/kg; 100 mg/kg
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Administration:i.p.; single dose 10 minutes pre-histone injection
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Result:Prevented histone-induced thrombocytopenia (maintained circulating platelet counts near control levels).
Prevented histone-induced anemia (maintained circulating red blood cell counts near control levels and reduced splenic hemoglobin accumulation to near control levels).
Reduced circulating alanine aminotransferase, lactate dehydrogenase, and creatinine levels in a dose-dependent manner, with 100 mg/kg providing the greatest reduction.
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Animal Model:Wistar (male, 8-12 weeks old, 250-350 g, CLP-induced sepsis model)[2]
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Dosage:50 mg/kg
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Administration:i.p.; four total doses: 5 minutes pre-CLP, 5, 10, 15 hours post-CLP
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Result:Resulted in 100% survival of rats at 20 hours post-CLP (compared to reduced survival in untreated controls).
Normalized circulating alanine aminotransferase and creatinine levels, preventing CLP-induced liver and kidney damage.
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Animal Model:Wistar (male, 8-12 weeks old, 250-350 g, skin flap ischemia-reperfusion injury model)[1]
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Dosage:50 mg/kg
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Administration:i.p.; four total doses: 5 minutes pre-clamp, 5 minutes post-clamp removal, 24 hours post-surgery, 48 hours post-surgery
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Result:Significantly increased the viable area of the ischemic skin flap, with consistent improvement observed across treated rats.
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Animal Model:C57BL/6 (male, 8 weeks of age, histone-induced deep vein thrombosis model)[1]
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Dosage:50 mg/kg
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Administration:i.v.; single dose 5 minutes post-histone injection
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Result:Almost completely inhibited histone-induced DVT, with thrombus weights reduced to near sham-operated control levels.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 401513-39-1
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Masse moléculaire 1070.64
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Formule C13H17Na7O32S7
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SMILES
O=[S](O[C@H]([C@H]1O[S](=O)(O[Na])=O)[C@@H]([C@H](O[C@H]1OC)CO[S](=O)(O[Na])=O)O[C@H](O[C@@H]2CO[S](=O)(O[Na])=O)[C@@H]([C@H]([C@@H]2O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)(O[Na])=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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