Topixantrone
Topixantrone (BBR 3576) is an antitumor agent, and shows antitumor activity on prostate carcinoma.
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- CAS No.: 156090-18-5
- Formule: C21H26N6O2
- Masse moléculaire:394.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LoVo | IC50 |
0.3 μg/mL
Compound: 13x
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In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
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[PMID: 9876113] |
| LoVo | IC50 |
57 μg/mL
Compound: 13x
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In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
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[PMID: 9876113] |
Chemical Information
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CAS No. 156090-18-5
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Masse moléculaire 394.47
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Formule C21H26N6O2
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SMILES
O=C1C2=C(C3=NN(CCNCCO)C4=CC=C(C1=C34)NCCN(C)C)C=NC=C2
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Synonyms
BBR 3576
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topixantrone Related Classifications
HY-105164 Related Classifications
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