Chondroitinase ABC
Based on 2 publication(s) in Google Scholar
Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury.
For research use only. We do not sell to patients.
- CAS No.: 9024-13-9
- Molecular Weight:120 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chondroitinase ABC
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Biological Activity
Description
In Vitro
Product Information
The molecular weight of chondroitinase ABC is ~120 kDa (gel filtration and sucrose gradient ultracentrifugation), and SDS-PAGE shows two different subunits with molecular weights of 86 kDa and 32 kDa, respectively. The optimal reaction conditions are pH 8.0 (chondroitin sulfate), pH 6.8 (hyaluronic acid), and 37°C.
Activator: 0.05 M acetate
Inhibitor: 1 mM Zn2+
Instructions
Redissolve in 0.01% BSA aqueous solution. Subsequently, dilute with a buffer containing 50 mM Tris HCl (pH 8.0), 60 mM sodium acetate, and 0.02% BSA, and prepare the solution before use.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 9024-13-9
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Appearance Solid
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Molecular Weight 120 kDa
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Color White to off-white
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SMILES
[Chondroitinase ABC]
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Synonyms
ChABC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Res
The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma. [Abstract]2025 May 2;85(9):1628-1643. PMID: 39992715 -
Brain Behav Immun
Dorsal root ganglion macrophages mediate osteoarthritis pain via disruption of sensory neuron perineuronal nets. [Abstract]2026 Aug:136:106567. PMID: 41905490
Protocols
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Carbohydrates and Mucins: Alcian Blue/Alcian Blue-PAS Staining
Alcian Blue (AB) staining is a cationic copper phthalocyanine dye-based histochemical method that binds electrostatically to negatively charged acidic mucopolysaccharides (glycosaminoglycans and sialomucins), enabling visualization of acidic carbohydrate-rich structures such as epithelial mucins, cartilage matrix, and mast cell granules. Periodic Acid-Schiff (PAS) reaction detects neutral mucopolysaccharides and glycoconjugates by oxidizing vicinal diols to aldehydes, which subsequently react with Schiff reagent to produce a magenta signal. The combined Alcian Blue-PAS (AB-PAS) method allows simultaneous differentiation of acidic (blue) and neutral (magenta) mucins in the same tissue section, enabling mucin subtype discrimination in epithelial tissues and pathological lesions.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chondroitinase ABC Related Classifications
HY-P2727 Related Classifications
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