CK1-IN-2 hydrochloride
Based on 1 publication(s) in Google Scholar
CK1-IN-2 (compound Nr.4) hydrochloride is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1383377-49-8
- Formula: C17H13ClFN3O2
- Molecular Weight:345.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) CK1-IN-2 hydrochloride
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Biological Activity
Description
In Vitro
CK1-IN-2 (0.02-10 μM, 72 h) promotes myotube fusion in FSHD cells [1].
CK1-IN-2 (10 μM, 72 h) can significantly reduce the inhibitory effect of Losmapimod on myotube fusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1383377-49-8
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Molecular Weight 345.76
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Formula C17H13ClFN3O2
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SMILES
O=C1OCC2=NC=CC(C3=CN(C)N=C3C4=CC=C(F)C=C4)=C12.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Neuron
Cell-type-focused compound screen in human organoids reveals CK1 inhibition protects cone photoreceptors from death. [Abstract]2026 Jul 1;114(13):2347-2366.e12. PMID: 41916277
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CK1-IN-2 hydrochloride Related Classifications
HY-153866A Related Classifications
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