Colistin B
Colistin B (Polymyxin E2) is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B exerts apoptotic effects on human renal proximal tubular cells. Colistin B induces mild to moderate renal histological damage in mouse models. Colistin B can be used in the research of multidrug-resistant Gram-negative bacterial infections.
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- CAS No.: 7239-48-7
- 화학식: C52H98N16O13
- 분자량:1155.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Colistin B (0-32 mg/L; 18-20 h) inhibits the growth of Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, and Enterobacter cloacae strains in vitro with MIC values ranging from 0.25 to 4 μg/mL[1].
Colistin B (0.75 mM) induces significantly less in vitro apoptotic cell death in human kidney proximal tubular HK-2 cells, with 67.8% cell viability at a concentration of 0.75 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Colistin B (12 mg/kg; s.c.; every 2 hours; accumulated dose of 72 mg/kg) causes mild to moderate renal histological damage in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (22 to 28 g; neutropenic; challenged intravenously with Pseudomonas aeruginosa ATCC 27853)[1]
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Dosage:4 mg/kg
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Administration:i.v.; single dose
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Result:Achieved a mean reduction in blood bacterial burden of -3.99 log10 CFU/mL relative to saline control.
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Animal Model:Mice[1]
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Dosage:12 mg/kg; accumulated dose of 72 mg/kg
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Administration:s.c.; every 2 hours
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Result:Caused renal histological damage scored as semi-quantitative score (SQS) +1 to +2, corresponding to mild to moderate acute tubular damage including tubular dilation, degeneration, necrosis of tubular epithelial cells, and tubular casts.
Chemical Information
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CAS No. 7239-48-7
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분자량 1155.43
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화학식 C52H98N16O13
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SMILES
CC(C)CCCCC(N[C@@H](CCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCN)C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC1)=O)([H])[C@H](O)C)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)=O)=O)=O
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Synonyms
Polymyxin E2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colistin B Related Classifications
HY-184858 Related Classifications
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- Colistin B
- 7239-48-7
- Polymyxin E2
- Polymyxin E 2
- Polymyxin E-2
- Bacterial
- Apoptosis
- mouse models
- Pseudomonas aeruginosa
- multidrug-resistant Gram-negative bacteria
- Acinetobacter baumannii
- human kidney proximal tubular cells
- multidrug-resistant Gram-negative bacterial infections
- Klebsiella pneumoniae
- neutropenic mice
- Enterobacter cloacae
- HK-2 cells
- Inhibitor
- inhibitor
- inhibit