Colistin B sulfate
Colistin B (Polymyxin E2) sulfate is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B sulfate exerts apoptotic effects on human renal proximal tubular cells. Colistin B sulfate induces mild to moderate renal histological damage in mouse models. Colistin B sulfate can be used in the research of multidrug-resistant Gram-negative bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 1338055-88-1
- Formula: C52H98N16O13.xH2SO4
- Molecular Weight:1155.43 (free base)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Colistin B (0-32 mg/L; 18-20 h) sulfate inhibits the growth of Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, and Enterobacter cloacae strains in vitro with MIC values ranging from 0.25 to 4 μg/mL[1].
Colistin B (0.75 mM) sulfate induces significantly less in vitro apoptotic cell death in human kidney proximal tubular HK-2 cells, with 67.8% cell viability at a concentration of 0.75 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Colistin B (12 mg/kg; s.c.; every 2 hours; accumulated dose of 72 mg/kg) sulfate causes mild to moderate renal histological damage in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (22 to 28 g; neutropenic; challenged intravenously with Pseudomonas aeruginosa ATCC 27853)[1]
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Dosage:4 mg/kg
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Administration:i.v.; single dose
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Result:Achieved a mean reduction in blood bacterial burden of -3.99 log10 CFU/mL relative to saline control.
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Animal Model:Mice[1]
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Dosage:12 mg/kg; accumulated dose of 72 mg/kg
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Administration:s.c.; every 2 hours
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Result:Caused renal histological damage scored as semi-quantitative score (SQS) +1 to +2, corresponding to mild to moderate acute tubular damage including tubular dilation, degeneration, necrosis of tubular epithelial cells, and tubular casts.
Chemical Information
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CAS No. 1338055-88-1
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Molecular Weight 1155.43 (free base)
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Formula C52H98N16O13.xH2SO4
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Synonyms
Polymyxin E2 sulfate
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Sequence
{MOA}-{Dab}-Thr-{Dab}-{Dab}-{Dab}-{d-Leu}-Leu-{Dab}-{Dab}-Thr (lactam: Dab4-Thr10)
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Sequence Shortening
{MOA}-{Dab}-T-{Dab}-{Dab}-{Dab}-{d-Leu}-L-{Dab}-{Dab}-T (lactam: Dab4-Thr10)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colistin B sulfate Related Classifications
HY-107027 Related Classifications
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- Colistin B
- 1338055-88-1
- Polymyxin E2
- Polymyxin E 2
- Polymyxin E-2
- Bacterial
- Apoptosis
- mouse models
- Pseudomonas aeruginosa
- multidrug-resistant Gram-negative bacteria
- Acinetobacter baumannii
- human kidney proximal tubular cells
- multidrug-resistant Gram-negative bacterial infections
- Klebsiella pneumoniae
- neutropenic mice
- Enterobacter cloacae
- HK-2 cells
- Inhibitor
- inhibitor
- inhibit