Colominic acid sodium salt
Based on 1 publication(s) in Google Scholar
Colominic acid sodium salt (Polysialic acid sodium salt) could be naturally isolated from the cell wall of Escherichia coli and animals, gives a red color which has an absorption maximum at 530 nm. Colominic acid sodium salt (Polysialic acid sodium salt) possesses anti-bacterial activity.
For research use only. We do not sell to patients.
- Purity : 99.73%
- CAS No.: 70431-34-4
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Colominic acid sodium salt
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Biological Activity
Description
In Vitro
Colominic acid (Polysialic acid) is an form of N-glycosylation with great specificity for its limited central nervous system targets, including the cell adhesion molecules neural cell adhesion molecule (NCAM) and synaptic cell adhesion molecule 1 (SynCAM1), and the receptor, neuropilin-2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 70431-34-4
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Appearance Solid
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](NC(C)=O)[C@H]([C@@H](O)[C@H](O)CO)O[C@](C(O[Na])=O)(O[C@@H]([C@H](O)[C@H]2[C@H](NC(C)=O)[C@@H](O)C[C@@](C(O[Na])=O)(O[C@@H]([C@H](O)[C@H]3[C@H](NC(C)=O)[C@@H](O)C[C@@](C(O[Na])=O)(O)O3)CO)O2)CO)C1.[n]
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Synonyms
Polysialic acid sodium salt
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Structure Classification
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Initial Source
Escherichia coli K1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread. [Abstract]2026 Jun 16;123(24):e2536989123. PMID: 42268890
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Guy T. Barry, et al. COLOMINIC ACID, A POLYMER OF N-ACETYLNEURAMINIC ACID. J Exp Med. 1958 Apr 1;107(4):507-21. [Content Brief]
[2]. Osama I Alwassil, et al. Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection. PLoS One. 2019 Oct 16;14(10):e0223413. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colominic acid sodium salt Related Classifications
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