CRBN ligand-678
CRBN ligand-678 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-678 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- CAS No.: 458151-38-7
- Formula: C17H13N3O4
- Molecular Weight:323.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cereblon |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
>50 μM
Compound: 1c
|
Cytotoxicity against human DLD1 cells by MTT assay
Cytotoxicity against human DLD1 cells by MTT assay
|
[PMID: 19394719] |
| HL-60 | IC50 |
>50 μM
Compound: 1c
|
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
|
[PMID: 19394719] |
| HT-29 | IC50 |
>50 μM
Compound: 1c
|
Cytotoxicity against human HT-29 cells by MTT assay
Cytotoxicity against human HT-29 cells by MTT assay
|
[PMID: 19394719] |
| HUVEC | IC50 |
>50 μM
Compound: 1c
|
Cytotoxicity against HUVEC by MTT assay
Cytotoxicity against HUVEC by MTT assay
|
[PMID: 19394719] |
| ST486 | IC50 |
>50 μM
Compound: 1c
|
Cytotoxicity against human ST486 cells by MTT assay
Cytotoxicity against human ST486 cells by MTT assay
|
[PMID: 19394719] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 458151-38-7
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Molecular Weight 323.31
-
Formula C17H13N3O4
-
SMILES
O=C1NC(=O)C(N2C(=O)C=3C=CC=C4C=C(N)C=C(C2=O)C43)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)