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Cat. No.: HY-D0015A

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Cresol Red sodium

Cresol Red sodium is a colorimetric pH indicator. Cresol Red sodium serves as an optical sensor for monitoring carbonic anhydrase-catalyzed reactions and as a colorimetric dye that responds to hydrogen ions generated during DNA synthesis. Cresol Red sodium can be used in the research of hepatitis A and COVID-19.

For research use only. We do not sell to patients.

CAS No.: 62625-29-0
Formula: C₂₁H₁₇NaO₅S
Molecular Weight:404.41

Storage:

RT, protect from light, stored under nitrogen.

In solvent -80°C, 1 year , -20°C, 6 months

Data Sheet (282 KB)

Cresol Red sodium Chemical Structure

CAS No.: 62625-29-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Emission (Em)
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Cresol Red sodium (3.71 mM; 6 h) enables naked-eye detection of temperature changes through visualizable DNA synthesis, allowing detection of short-term temperature exposure lasting only 2 h in cold-chain logistics while ensuring stability at room temperature^[2].
Cresol Red sodium salt serves as a pH indicator in solution for colorimetric RT-LAMP detection of the SARS-CoV-2 N gene^[11].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Emission (Em)

689

Chemical Information

CAS No. 62625-29-0
Appearance Solid
Molecular Weight 404.41
Formula C₂₁H₁₇NaO₅S
Color Brown to dark brown
SMILES

O=S1(OC(C2=CC=C(O[Na])C(C)=C2)(C3=CC=C(O)C(C)=C3)C4=CC=CC=C41)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

RT, protect from light, stored under nitrogen

In solvent	-80°C	1 year
	-20°C	6 months

Protocols

All Cell Biology

EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
BrdU Incorporation Assay
Bromodeoxyuridine (BrdU) incorporation assay is based on the principle that BrdU, a thymidine analog, is incorporated into newly synthesized DNA during the S phase of the cell cycle, thereby serving as a marker of DNA replication and cellular proliferation. Incorporated BrdU can be detected using anti-BrdU antibodies following DNA denaturation, enabling visualization or quantification of proliferating cells through immunochemical detection methods such as immunofluorescence or immunohistochemistry.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jerónimo PC, et al. Flow-through sol-gel optical biosensor for the colorimetric determination of acetazolamide. The Analyst. 2005 Aug;130(8):1190-7.

[2]. Kim J, et al. Programmable one-pot polymerase-mediated DNA synthesis via temperature control. Nature communications. 2026 Jul 02;17(1):8241.

[3]. Huang T, et al. Polymer Vesicle Sensor for Visual and Sensitive Detection of SO in Water. Langmuir : the ACS journal of surfaces and colloids. 2017 Jan 10;33(1):340-346.

[4]. Muller KO. Effect of Streptomycin on the Host–Pathogen Relationship of a Fungal Phytopathogen. Nature. 1954 Nov 6;174(4436):878-9.

[5]. An T, et al. Development of Visual Loop-Mediated Isothermal Amplification Assays for Foodborne Hepatitis A Virus. Foods (Basel, Switzerland). 2025 Mar 10;14(6):934.

[6]. Liu Q, et al. A continuous thermochromic energy storage material with three colors based on two color-changing mechanisms. Journal of Energy Storage. 2025 Feb 15;109:115211.

[7]. Mukhtar F. Dual S-scheme heterojunction ZnO–V2O5–WO3 nanocomposite with enhanced photocatalytic and antimicrobial activity. Materials Chemistry and Physics. 2021 Apr 15;263:124372.

[8]. Chen Y, et al. Advancing Food Safety: The Role of Isothermal Nucleic Acid Amplification Techniques in Allergen Detection. Food Analytical Methods. 2026 Oct;19(10):286.

[9]. Stanciu MC, et al. An Adaptive Cholic Acid Dimer for Selective Encapsulation. International journal of molecular sciences. 2026 May 25;27(11):4765.

[10]. Lee S, et al. Colorimetric assay for β-lactamase activity using cocktail of penicillin and 4-(2-pyridylazo)resorcinol (PAR)–2Hg²⁺ complex. Dyes and Pigments. 2017;137:204-209.

[11]. Wang J. A RAPID PAPER-BASED COLORIMETRIC MOLECULAR TEST FOR SARS-COV-2 POINT-OF-CARE DIAGNOSTIC (Doctoral dissertation.

[12]. Wu L, et al. A novel conductive carbon-based forward osmosis membrane for dye wastewater treatment. Chemosphere. 2022 Dec;308(Pt 2):136367.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Minimum order quantity

100 mg

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