2. Immunology/Inflammation
  3. PSMA
  4. Cy5-ZW2-617

Cy5-ZW2-617 is a PSMA ligand with a IC50 of 4.39 nM. Cy5-ZW2-617 specifically binds to PSMA and is thereby internalized by PSMA-positive cells. Cy5-ZW2-617 shows uptake in PSMA-positive tumor cells and tumor xenografts in mice. Cy5-ZW2-617 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

Cy5-ZW2-617

Cy5-ZW2-617 Chemical Structure

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Cy5-ZW2-617 Related Antibodies

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Description

Cy5-ZW2-617 is a PSMA ligand with a IC50 of 4.39 nM. Cy5-ZW2-617 specifically binds to PSMA and is thereby internalized by PSMA-positive cells. Cy5-ZW2-617 shows uptake in PSMA-positive tumor cells and tumor xenografts in mice. Cy5-ZW2-617 can be used for the research of prostate cancer[1].

In Vitro

Cy5-ZW2-617 (Compound 10) (2.5-10 μM; 2 h) is efficiently and specifically endocytosed by PSMA-positive PC3-PIP and LNCaP cells, and then mainly localizes to the perinuclear compartment, while no uptake is observed in PSMA-negative PC3 flu cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cy5-ZW2-617 Related Antibodies

Immunofluorescence[1]

Cell Line: PSMA-positive PC3-PIP, LNCaP cells
Concentration: 2.5 μM or 10 μM
Incubation Time: 2 h
Result: Showed efficient internalization into PSMA-positive PC3-PIP and LNCaP cells, with highest fluorescence intensity observed in perinuclear compartments.
In Vivo

Cy5-ZW2-617 (20 nmol; retro-orbital injection; single dose) is specifically taken up in PSMA-positive prostate cancer xenograft mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: athymic nude-Fox1nu (male, 6 weeks old, subcutaneous xenograft modeling with PSMA-positive PC3-PIP and PSMA-negative PC3 flu cells)[1]
Dosage: 20 nmol
Administration: retro-orbital; single dose
Result: Exhibited high, specific uptake in PSMA-positive PC3-PIP tumors, with low uptake in PSMA-negative PC3 flu tumors.
Reduced uptake in head and neck region 28-fold compared to reference compound Cy5-617 8.
Improved tumor-to-muscle ratio 4-fold compared to reference compound Cy5-617 8.
Improved tumor-to-head and neck region ratio 12-fold compared to reference compound Cy5-617 8.
Molecular Weight

1965.27

Formula

C89H122N17NaO24S4
SMILES

O=C(N[C@@H](C(O)=O)CCCCNC([C@@H](NC(C1CCC(CNC([C@@H](NC([C@H](CCN2C=C(N=N2)C[N+](CCC[S-](=O)(=O)=O)(C)C)NC(CCCCCN(/C3=C/C=C/C=C/C(C4(C)C)=[N+](C5=C4C=C(S(=O)(O[Na])=O)C=C5)C)C6=C(C=C(S(=O)([O-])=O)C=C6)C3(C)C)=O)=O)CCN7C=C(N=N7)C[N+](CCC[S-](=O)(=O)=O)(C)C)=O)CC1)=O)CC8=CC=C9C=CC=CC9=C8)=O)N[C@@H](C(O)=O)CCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cy5-ZW2-617 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cy5-ZW2-617PSMAProstate-specific membrane antigenPSMA ligandPC3-PIP cellsLNCaP cellsathymic nude-Fox1nu miceprostate cancerInhibitorinhibitorinhibit

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