Cy5-ZW2-617
Cy5-ZW2-617 is a PSMA ligand with a IC50 of 4.39 nM. Cy5-ZW2-617 specifically binds to PSMA and is thereby internalized by PSMA-positive cells. Cy5-ZW2-617 shows uptake in PSMA-positive tumor cells and tumor xenografts in mice. Cy5-ZW2-617 can be used for the research of prostate cancer.
For research use only. We do not sell to patients.
- Formula: C89H123N17O24S4
- Molecular Weight:1943.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cy5-ZW2-617 (Compound 10) (2.5-10 μM; 2 h) is efficiently and specifically endocytosed by PSMA-positive PC3-PIP and LNCaP cells, and then mainly localizes to the perinuclear compartment, while no uptake is observed in PSMA-negative PC3 flu cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PSMA-positive PC3-PIP, LNCaP cells
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Concentration:2.5 μM or 10 μM
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Incubation Time:2 h
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Result:Showed efficient internalization into PSMA-positive PC3-PIP and LNCaP cells, with highest fluorescence intensity observed in perinuclear compartments.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:athymic nude-Fox1nu (male, 6 weeks old, subcutaneous xenograft modeling with PSMA-positive PC3-PIP and PSMA-negative PC3 flu cells)[1]
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Dosage:20 nmol
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Administration:retro-orbital; single dose
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Result:Exhibited high, specific uptake in PSMA-positive PC3-PIP tumors, with low uptake in PSMA-negative PC3 flu tumors.
Reduced uptake in head and neck region 28-fold compared to reference compound Cy5-617 8.
Improved tumor-to-muscle ratio 4-fold compared to reference compound Cy5-617 8.
Improved tumor-to-head and neck region ratio 12-fold compared to reference compound Cy5-617 8.
Chemical Information
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Molecular Weight 1943.29
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Formula C89H123N17O24S4
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SMILES
C[N+](CCCS(=O)([O-])=O)(C)CC(N=N1)=CN1CC[C@H](NC([C@H](CCN2C=C(N=N2)C[N+](CCCS(=O)([O-])=O)(C)C)NC(CCCCCN(/C3=C/C=C/C=C/C(C4(C)C)=[N+](C5=C4C=C(S(=O)([O-])=O)C=C5)C)C6=C(C=C(S(=O)(O)=O)C=C6)C3(C)C)=O)=O)C(NC[C@H]7CC[C@@H](CC7)C(N[C@@H](CC8=CC(C=CC=C9)=C9C=C8)C(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cy5-ZW2-617 Related Classifications
HY-182240 Related Classifications
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