D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium salt
Based on 1 Customer Validation
D-myo-Inositol-1,2,4,5-tetraphosphate (DL-Ins-(1,2,4,5)P4) tetrasodium is raracemic regioisomer of myo-inositol tetrakisphosphates (IP4s). D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium is an Ins(1,4,5)P3 receptor agonist with a Ki of 11 nM. D-myo-Inositol-1,2,4,5-tetraphosphate tetrasodium induces Ca2+ mobilization with an EC50 value of 0.22 μM in CHO cells.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 154278-46-3
- Formula: C6H12Na4O18P4
- Molecular Weight:588.00
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 154278-46-3
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Appearance Solid
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Molecular Weight 588.00
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Formula C6H12Na4O18P4
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Color White to off-white
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SMILES
O[C@@H]1[C@H]([C@@H]([C@H]([C@H]([C@H]1OP(O)(O[Na])=O)OP(O)(O[Na])=O)O)OP(O)(O[Na])=O)OP(O)(O[Na])=O
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Synonyms
Ins(1,2,4,5)P4 tetrasodium salt; 1,2,4,5-IP4 tetrasodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (85.03 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7007 mL | 8.5034 mL | 17.0068 mL | 42.5170 mL |
| 5 mM | 0.3401 mL | 1.7007 mL | 3.4014 mL | 8.5034 mL | |
| 10 mM | 0.1701 mL | 0.8503 mL | 1.7007 mL | 4.2517 mL | |
| 15 mM | 0.1134 mL | 0.5669 mL | 1.1338 mL | 2.8345 mL | |
| 20 mM | 0.0850 mL | 0.4252 mL | 0.8503 mL | 2.1259 mL | |
| 25 mM | 0.0680 mL | 0.3401 mL | 0.6803 mL | 1.7007 mL | |
| 30 mM | 0.0567 mL | 0.2834 mL | 0.5669 mL | 1.4172 mL | |
| 40 mM | 0.0425 mL | 0.2126 mL | 0.4252 mL | 1.0629 mL | |
| 50 mM | 0.0340 mL | 0.1701 mL | 0.3401 mL | 0.8503 mL | |
| 60 mM | 0.0283 mL | 0.1417 mL | 0.2834 mL | 0.7086 mL | |
| 80 mM | 0.0213 mL | 0.1063 mL | 0.2126 mL | 0.5315 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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