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Cat. No.: HY-172797

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DDR Inhibitor 2

DDR Inhibitor 2 (compound 5a) is a discoidin domain receptor (DDR) inhibitor with an IC₅₀ of 0.125 μM. DDR Inhibitor 2 can be used for study of fibrotic diseases.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₃N₇O
Molecular Weight:389.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DDR Inhibitor 2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DDR Inhibitor 2 (compound 5a) is a discoidin domain receptor (DDR) inhibitor with an IC₅₀ of 0.125 μM. DDR Inhibitor 2 can be used for study of fibrotic diseases^[1].

All Discoidin Domain Receptor Isoforms :

DDR1
DDR2

Chemical Information

Molecular Weight 389.45
Formula C₂₁H₂₃N₇O
SMILES

CN1C=C2C3=NC(NC4=CN(CCCNCCOC5=CC=C2C=C5)N=C4)=NC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Carzaniga L, et al. Macrocyclization: Enhancing Drug-like Properties of Discoidin Domain Receptor Kinase Inhibitors. ACS Med Chem Lett. 2025 Apr 7;16(5):784-789. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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