3432-99-3
Chemical Structure
Folitixorin
Synonym(s): 5,10-Methylenetetrafolate; ANX-510 free acid
- CAS. Nr.: 3432-99-3
- Formula:C20H23N7O6
- Molecular Weight:457.44
IUPAC Name: (4-(3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamic acid
InChIKey: QYNUQALWYRSVHF-ABLWVSNPSA-N
SMILES: O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C4)C3)NC(N)=N1
Biological Activity: Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Folitixorin | 83.37% | Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer. | ||||||||||||||||||||
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Folitixorin-d4 | Folitixorin-d4 (5,10-Methylenetetrafolate-d4; ANX-510 (free acid)-d4) is the deuterium labeled Folitixorin (HY-14769). Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research. | |||||||||||||||||||||
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References
- [1]. Shirasaka T, et al. Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer chemotherapy and pharmacology. 1993;32(3):167-72.
- [2]. Chen YL, et al. Artificial intelligence-guided discovery of a lead compound with antifolate-like activity against bacterial and human thymidylate synthases. Frontiers in cellular and infection microbiology. 2026;16:1816809. [Content Brief]
- [3]. M. J. Cantwell et al. Antitumor activity of combination 5,10-methylenetetrahydrofolate, 5-fluorouracil, and anti-vascular endothelial growth factor against human colorectal HT-29 tumors in nude mice. J Clin Oncol 22, 3768-3768(2004).
