F1-ispinesib
F1-ispinesib is a heterobifunctional F1-autophagy degrader, composed of an RNA-binding fragment (F1) and the LC3B ligand Ispinesib (HY-50759). F1-ispinesib induces degradation of COL15A1 mRNA via an LC3B-dependent macroautophagy mechanism. F1-ispinesib inhibits cell proliferation and enhances migration of human aortic smooth muscle cells.
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- Formel: C51H52Cl3N5O4
- Molecular Weight:905.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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Molecular Weight 905.35
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Formel C51H52Cl3N5O4
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SMILES
CC1=CC=C(C=C1)C(N([C@H](C(C)C)C2=NC3=C(C(N2CC4=CC=CC=C4)=O)C=CC(Cl)=C3)CCCNC(CCC(N([C@H]5CC[C@H](C6=C5C=CC=C6)C7=CC=C(C(Cl)=C7)Cl)C)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
F1-ispinesib Related Classifications
HY-180188 Related Classifications
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