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Art. -Nr.: HY-160209

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KIO-301

KIO-301 is a photosensitizer with selective retinal ganglion cell uptake properties. KIO-301 acts on HCN channels and endogenous voltage-gated cation channels, thereby enabling photoswitch-mediated photoresponses and light-driven action potential generation. KIO-301 confers rapid and reliable light-evoked spike responses in retinal explants from mouse models of retinal degeneration, producing sustained light-evoked responses. KIO-301 can be used in research related to retinal degeneration.

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CAS. Nr.: 1643463-61-9
Formel: C₂₉H₃₈BrN₅O
Molecular Weight:552.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

KIO-301 Chemical Structure

CAS. Nr.: 1643463-61-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

KIO-301 (100 µM; 30 min) confers light-evoked RGC firing responses in rd1 mouse retinal explants, supporting its biological activity^[1]^[2].
KIO‑301 enters RGCs through the P2X7 large-pore channel highly expressed in degenerated retinas, non-covalently binds to the intracellular domain of HCN channels, and relies on light-controlled reversible isomerization to regulate HCN channel opening and closing and modulate Na⁺ influx, thereby controlling RGC depolarization and action potential firing^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KIO‑301 (7.5-50 µg; single intravitreal injection) achieves partial restoration of light perception, improves performance on visually guided locomotor functional tasks, and enhances stimulus-evoked BOLD‑fMRI signals in the primary visual cortex^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 1643463-61-9
Molecular Weight 552.55
Formel C₂₉H₃₈BrN₅O
SMILES

O=C(C[N+](CC)(CC)CC)NC1=CC=C(C=C1)/N=N/C2=CC=C(N(CC)CC3=CC=CC=C3)C=C2.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Casson RJ, et al. Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial. Nature medicine. 2026 May;32(5):1865-1870.

[2]. Casson R, et al. Vision restoration using a light-responsive small molecule photoswitch (KIO-301) in advanced retinitis pigmentosa: the ABACUS-1 phase 1/2 clinical trial. Research Square, 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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KIO-301