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Cat. No.: HY-U00206

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D2343

D2343 is a β2-adrenoceptor agonist and also is an α1- adrenoceptor inhibitor.

For research use only. We do not sell to patients.

CAS No.: 72734-63-5
Formula: C₂₀H₂₇NO₃
Molecular Weight:329.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

D2343 Chemical Structure

CAS No.: 72734-63-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

D2343 is a β2-adrenoceptor agonist and also is an α1- adrenoceptor inhibitor.

IC₅₀ & Target

β2-adrenoceptor^[1]
α1- adrenoceptor^[1]

All Adrenergic Receptor Isoforms :

In Vitro

D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as Terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity^[1]. The beta 2-agonistic and alpha 1-antagonistic drug D2343 inhibits the evoked contractions in a concentration related fashion with 50% effect at 9.6 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D2343 has been compared to the beta 2-agonist Terbutaline on oestrogenized uterine preparations from rat and rabbit and in myometrial strips from homo. D2343 has shown an ability to relax the uterine muscles to the same degree as Terbutaline or even more, especially when the two drugs are compared in preparations from rabbit and rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 72734-63-5
Molecular Weight 329.43
Formula C₂₀H₂₇NO₃
SMILES

OC(C1=CC=C(O)C=C1)CNC(C)(C)CCC2=C(C=CC=C2)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Olsson OA, et al. The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):391-7. [Content Brief]

[2]. Olsson OA, et al. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol (Copenh). 1985 May;56(5):427-30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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D2343

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

D2343 Related Classifications

HY-U00206 Related Classifications