country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-112005G

Copy Link Print Information

DOPE (GMP)

(Synonyms: Dioleoylphosphatidylethanolamine (GMP); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP))

Customer Review

Based on 1 Customer Validation

DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 4004-05-1
Formula: C₄₁H₇₈NO₈P
Molecular Weight:744.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE (GMP) Chemical Structure

CAS No.: 4004-05-1

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

GPX4

ACSL4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

All ACSL Family Isoforms :

ACSL4
ACSL5

In Vitro

FITC-labeled DOPE GMP (2 h) is internalized by IEC-6 rat intestinal epithelial cells within 2 hours, and fluorescence is detectable in both the cytoplasm and nucleus^[1].
DOPE GMP (5 μg/mL; 1 h) restores the migratory capacity of IEC-6 rat intestinal epithelial cells inhibited by LPS^[1].
DOPE GMP (5 μg/mL; 1 h) restores the migration and proliferation capacities, as well as the expression of tight junction proteins (ZO-1, occludin), in RSL3-induced ferroptotic rat intestinal epithelial cells IEC-6^[1].
DOPE GMP enhances the uptake efficiency of mesenchymal stem cells for AMSC-MP, improves the cell adhesion ability to scaffolds, upregulates the expression of osteogenesis-related gene RUNX2, and enhances in vitro osteogenic differentiation capacity. Moreover, this formulation exhibits excellent biocompatibility and does not exert adverse effects on cell viability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

LPS-stimulated rat intestinal epithelial IEC-6 cells
Concentration:

5 µg/mL
Incubation Time:

1 h (pre-incubation); 6 h (scratch monitoring)
Result:

Restored LPS-inhibited IEC-6 cell migration capacity to near control levels, as measured by relative migration index.

In Vivo

DOPE GMP (1 mg/kg; p.o.; 3 times daily; 4 days) reduces mortality, lowers NEC pathological injury scores, inhibits intestinal inflammation, restores intestinal barrier and proliferative function, and upregulates anti-ferroptosis marker GPX4 in neonatal SD rats with experimentally induced NEC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) Rat (neonatal, within 24 hours after birth, experimentally induced NEC)^[1]
Dosage:

1 mg kg^-1
Administration:

p.o.; 3 times daily; 4 days
Result:

Reduced neonatal rat mortality compared to the NEC-only group.
Significantly decreased the NEC pathological injury score of the terminal ileum.
Reduced relative mRNA expression of IL-1β and IL-6 in terminal ileum tissue.
Increased relative mRNA expression of tight junction proteins ZO-1 and occludin in terminal ileum tissue.
Improved intestinal epithelial proliferative ability compared to the NEC-only group.
Upregulated relative mRNA expression of the anti-ferroptosis factor GPX4 in terminal ileum tissue.
Reduced malondialdehyde (MDA) concentrations in terminal ileum tissue.

Chemical Information

CAS No. 4004-05-1
Molecular Weight 744.03
Formula C₄₁H₇₈NO₈P
SMILES

O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
Synonyms

Dioleoylphosphatidylethanolamine (GMP); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis. Food Funct. 2024;15(21):10811-10822. Published 2024 Oct 28. [Content Brief]

[2]. Hariawan B S, et al. Development of liposomal amniotic mesenchymal stem cell metabolite products (AMSC-MP) loaded-scaffold for in vitro osteogenesis induction[J]. European Polymer Journal, 2024, 220: 113482.

[3]. Bae Y, et al. DQAsomes Nanoparticles Promote Osteogenic Differentiation of Human Adipose‐derived Mesenchymal Stem Cells[J]. Bulletin of the Korean Chemical Society, 2018, 39(1): 97-104.

[4]. Cui GH, et al. RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease. Immun Ageing. 2019;16:10. Published 2019 May 13. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

DOPE (GMP)

All Glutathione Peroxidase Isoforms

All ACSL Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DOPE (GMP) Related Classifications

HY-112005G Related Classifications