TRIM44 - tripartite motif containing 44 Gene

Also Known as AN3; MC7; DIPB; HSA249128

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54765

About TRIM44

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,662,775-35,818,007 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 80 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM44 Products (1)

mRNA Protein Name
NM_017583.6 NP_060053.2 tripartite motif-containing protein 44

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17577209 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23460740 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
23460740 GOA
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26394807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM44 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (176 - 214)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 44

TRIM44 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIM44 Q96DX7 PBX3 Homo sapiens Q5JS98
Validated Y2H
25416956
Intra
TRIM44 Q96DX7 TRIM10 Homo sapiens Q9UDY6-2
Validated Y2H
32296183
Intra
TRIM44 Q96DX7 TRIM69 Homo sapiens Q86WT6
Validated Y2H
25416956
Intra
TRIM44 Q96DX7 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra
TRIM44 Q96DX7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aniridia 3

  • AN3

  • Aniridia, Type 3
Isolated Aniridia
Supraglottis Neoplasm

  • Neoplasm Of Supraglottis

  • Supraglottic Tumor
Gillespie Syndrome

  • GLSP

  • Aniridia, Cerebellar Ataxia And Mental Deficiency

  • Aniridia Cerebellar Ataxia Mental Deficiency

  • Aniridia, Cerebellar Ataxia, And Mental Retardation

  • Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome

  • Aniridia-Cerebellar Ataxia-Intellectual Disability

  • Aniridia-Cerebellar Ataxia-Mental Deficiency

  • Partial Aniridia-Cerebellar Ataxia-Oligophrenia

  • Aniridia, Cerebellar Ataxia, And Intellectual Disability
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

  • Wagr Syndrome

  • 11p Partial Monosomy Syndrome

  • Chromosome 11p13 Deletion Syndrome

  • Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

  • 11p Deletion Syndrome

  • Chromosome 11p Deletion Syndrome

  • Wagr Complex

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

  • Deletion 11p13

  • WAGR

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

  • Chromosome 11p Deletion

  • 11p Deletion

  • 11p Monosomy

  • Deletion 11p

  • Monosomy 11p

  • Partial Monosomy 11p

  • Agr Triad

  • Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

  • Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

  • Wagr Contiguous Gene Syndrome

  • Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

  • Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

  • Del(11)(P13)

  • Monosomy 11p13

  • Chromosome 11, Deletion 11p
Aniridia 1

  • Aniridia

  • Congenital Aniridia

  • AN1

  • An

  • Cataract With Late-Onset Corneal Dystrophy

  • Aplasia Of Iris

  • Absent Iris

  • Irideremia

  • Aniridia Ii, Formerly

  • An2, Formerly

  • An2

  • Aniridia Type Ii

  • Aniridia, Type 1

  • An-1

  • Absence Of Iris

  • Agenesis Of Iris

  • Congenital Absence Of Iris

  • Hereditary Aniridia

  • Sporadic Aniridia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183624 Trimer44NMe / Unkown
HY-RS15048 TRIM44 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21962 Trim44 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28479 Trim44 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM44 VGNC VGNC:36336
Canis familiaris TRIM44 VGNC VGNC:47823
Felis catus TRIM44 VGNC VGNC:66540
Rattus norvegicus TRIM44 RGD RGD:1304877
Mus musculus TRIM44 MGD MGI:1931835
Macaca mulatta TRIM44 VGNC VGNC:79168
Others TRIM44 NCBI