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INAVA - innate immunity activator Gene

Also Known as C1orf106

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55765

About INAVA

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,891,531-200,915,742 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in small intestine (RPKM 20.8), duodenum (RPKM 17.6) and 11 other tissues.

Summary

Involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in cytoplasm and nucleus. Implicated in inflammatory bowel disease 29. [provided by Alliance of Genome Resources, Apr 2022]

INAVA Products (4)

mRNA	Protein	Name
NM_001142569.3	NP_001136041.1	innate immunity activator protein isoform 2
NM_001367289.1	NP_001354218.1	innate immunity activator protein isoform 3
NM_001367290.1	NP_001354219.1	innate immunity activator protein isoform 4
NM_018265.4	NP_060735.4	innate immunity activator protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28436939	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adherens junction maintenance	IMP IMP: Inferred from mutant phenotype	29420262	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	29420262	GOA
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	28436939	GOA
involved in response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	28436939	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	28436939	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	28436939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INAVA Protein Structure

DUF3338

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
innate immunity activator protein	uncharacterized protein C1orf106

INAVA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INAVA	Q3KP66	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	29420262
Intra	INAVA	Q3KP66	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	29420262
Intra	INAVA	Q3KP66	CYTH2	Homo sapiens	Q99418	Anti Tag CoIP	33961781
Intra	INAVA	Q3KP66	CYTH2	Homo sapiens	Q99418	Anti Tag CoIP	29420262
Intra	INAVA	Q3KP66	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	33961781
Intra	INAVA	Q3KP66	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	28514442
Intra	INAVA	Q3KP66	CYTH1	Homo sapiens	Q15438	Anti Tag CoIP	29420262
Intra	INAVA	Q3KP66	CYTH1	Homo sapiens	Q15438	Anti Bait CoIP	29420262

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 29	IBD29 {Inflammatory Bowel Disease 29}
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Colitis
Idiopathic Peripheral Autonomic Neuropathy
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06803	INAVA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	INAVA	VGNC	VGNC:106387
Mus musculus	INAVA	MGD	MGI:1921579
Bos taurus	INAVA	VGNC	VGNC:30192
Felis catus	INAVA	VGNC	VGNC:62920
Rattus norvegicus	INAVA	RGD	RGD:1311892
Others	INAVA	NCBI