TGFBR3 - transforming growth factor beta receptor 3 Gene

Also Known as BGCAN; betaglycan

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7049

About TGFBR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,680,343-91,906,002 (from NCBI)

This gene has 11 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 40.0), ovary (RPKM 37.4) and 23 other tissues.

Summary

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta Receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

TGFBR3 Products (12)

mRNA	Protein	Name
XM_047429271.1	XP_047285227.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429254.1	XP_047285210.1	transforming growth factor beta receptor type 3 isoform X1
NM_001195683.2	NP_001182612.1	transforming growth factor beta receptor type 3 isoform b precursor
XM_047429255.1	XP_047285211.1	transforming growth factor beta receptor type 3 isoform X1
NM_001195684.1	NP_001182613.1	transforming growth factor beta receptor type 3 isoform b precursor
NR_036634.2
XM_047429256.1	XP_047285212.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429247.1	XP_047285203.1	transforming growth factor beta receptor type 3 isoform X1
XM_006710867.3	XP_006710930.1	transforming growth factor beta receptor type 3 isoform X1
XM_047429261.1	XP_047285217.1	transforming growth factor beta receptor type 3 isoform X2
XM_047429273.1	XP_047285229.1	transforming growth factor beta receptor type 3 isoform X3
NM_003243.5	NP_003234.2	transforming growth factor beta receptor type 3 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables BMP binding	IPI IPI: Inferred from physical interaction	18184661	GOA
enables SMAD binding	IMP IMP: Inferred from mutant phenotype	11157754	GOA
enables coreceptor activity	IDA IDA: Inferred from direct assay	10746731	GOA
contributes to protein binding	IPI IPI: Inferred from physical interaction	10746731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10746731	GOA
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	11157754	GOA
contributes to transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	11157754	GOA
enables transforming growth factor beta receptor activity	IDA IDA: Inferred from direct assay	12958365	GOA
enables transforming growth factor beta receptor activity, type III	IDA IDA: Inferred from direct assay	10746731	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	18184661	GOA
enables type II transforming growth factor beta receptor binding	IDA IDA: Inferred from direct assay	11157754	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	18184661	GOA
involved in cardiac epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18184661	GOA
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18184661	GOA
involved in immune response	IMP IMP: Inferred from mutant phenotype	16886151	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	14557487	GOA
involved in negative regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	30729664	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	29130787	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	29130787	GOA
involved in negative regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	30729664	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	18184661	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	11157754	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	30467960	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	30467960	GOA
involved in response to follicle-stimulating hormone	IDA IDA: Inferred from direct assay	14557487	GOA
involved in response to luteinizing hormone	IDA IDA: Inferred from direct assay	14557487	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	14557487	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12958365	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11157754	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12958365	GOA
part of inhibin-betaglycan-ActRII complex	IDA IDA: Inferred from direct assay	10746731	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	11157754	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGFBR3 Protein Structure

Zona_pellucida

0
200
400
600
800
851 a.a.

Protein Preferred Names	Protein Names
transforming growth factor beta receptor type 3	TGF-beta receptor type 3 TGF-beta receptor type III TGFR-3 betaglycan proteoglycan transforming growth factor beta receptor III

TGFBR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TGFBR3	Q03167	GIPC1	Homo sapiens	O14908	Pull Down	11546783
Intra	TGFBR3	Q03167	GIPC1	Homo sapiens	O14908	Y2H Array	11546783

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TGFBR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74521	TGFBR3/TGF-beta RIII Protein, Human (sf9, His)	Q03167 (G21-G781)	≥ 90%, as determined by reducing SDS-PAGE.

TGFBR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84476	TGFBR3 Antibody (YA4173)	WB, ELISA	Human, Mouse
HY-P84476A	TGFBR3 Antibody (YA4173)(PBS only)	WB, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Familial Cerebral Saccular Aneurysm	Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Disseminated Chorioretinitis
Acquired Hyperkeratosis	Acquired Keratoderma Keratoderma - Acquired Keratoderma, Acquired Keratosis Blennorrhagica
Lipodystrophy, Familial Partial, Type 6	FPLD6 Lipe-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 6 Lipe-Related Fpld Lipodystrophy, Familial Partial, Associated With Lipe Mutations Familial Partial Lipodystrophy Associated With Lipe Mutations Lipodystrophy, Familial Partial, 6
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14450	TGFBR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14451	Tgfbr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14452	Tgfbr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14453	TGFBR3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174529	Human TGFBR3 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TGFBR3	VGNC	VGNC:66137
Canis familiaris	TGFBR3	VGNC	VGNC:54077
Macaca mulatta	TGFBR3	VGNC	VGNC:78339
Rattus norvegicus	TGFBR3	RGD	RGD:61821
Mus musculus	TGFBR3	MGD	MGI:104637
Bos taurus	TGFBR3	VGNC	VGNC:49979
Others	TGFBR3	NCBI