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ACSF2 - acyl-CoA synthetase family member 2 Gene

Also Known as ACSMW; AVYV493

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80221

About ACSF2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,426,218-50,474,845 (from NCBI)

This gene has 25 transcripts (splice variants), 256 orthologues and 13 paralogues. Broad expression in kidney (RPKM 73.1), thyroid (RPKM 24.6) and 18 other tissues.

Summary

Enables medium-chain fatty acid-CoA Ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ACSF2 Products (6)

mRNA	Protein	Name
NM_001288968.2	NP_001275897.1	medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 1
NM_001288969.2	NP_001275898.1	medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 3
NM_001288970.2	NP_001275899.1	medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 4
NM_001288971.2	NP_001275900.1	medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 5
NM_001288972.2	NP_001275901.1	medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 5
NM_025149.6	NP_079425.3	medium-chain acyl-CoA ligase ACSF2, mitochondrial isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables medium-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	17762044	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSF2 Protein Structure

AMP-binding

AMP-binding_C

0
100
200
300
400
500
615 a.a.

Protein Preferred Names	Protein Names
medium-chain acyl-CoA ligase ACSF2, mitochondrial	PPARG binding, long chain fatty acid acyl Co-A ligase like

ACSF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACSF2	Q96CM8	MICOS13	Homo sapiens	Q5XKP0	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	MICOS13	Homo sapiens	Q5XKP0	Y2H Array	32296183
Intra	ACSF2	Q96CM8	SYNGR3	Homo sapiens	O43761	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	SYNGR3	Homo sapiens	O43761	Y2H Array	32296183
Intra	ACSF2	Q96CM8	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	ACSF2	Q96CM8	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	ACSF2	Q96CM8	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	ACSF2	Q96CM8	RDH10	Homo sapiens	Q8IZV5	Y2H Array	32296183
Intra	ACSF2	Q96CM8	RDH10	Homo sapiens	Q8IZV5	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	ACSF2	Q96CM8	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	ACSF2	Q96CM8	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	ACSF2	Q96CM8	C10orf67	Homo sapiens	Q8IYJ2-2	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	C10orf67	Homo sapiens	Q8IYJ2-2	Y2H Array	32296183
Intra	ACSF2	Q96CM8	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	ACSF2	Q96CM8	SIGLEC12	Homo sapiens	Q96PQ1	Validated Y2H	32296183
Intra	ACSF2	Q96CM8	SIGLEC12	Homo sapiens	Q96PQ1	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	SIGLEC12	Homo sapiens	Q96PQ1	Y2H Array	32296183
Intra	ACSF2	Q96CM8	CMTM5	Homo sapiens	Q96DZ9	Y2H	21516116
Intra	ACSF2	Q96CM8	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
Intra	ACSF2	Q96CM8	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	APOA5	Homo sapiens	Q6Q788	Y2H Array	32296183
Intra	ACSF2	Q96CM8	APOA5	Homo sapiens	Q6Q788	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	ACSF2	Q96CM8	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	SENP2	Homo sapiens	Q9HC62	Validated Y2H	32296183
Intra	ACSF2	Q96CM8	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	ACSF2	Q96CM8	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	ACSF2	Q96CM8	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	ACSF2	Q96CM8	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	ACSF2	Q96CM8	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00198	ACSF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22374	Acsf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28897	Acsf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACSF2	VGNC	VGNC:25562
Felis catus	ACSF2	VGNC	VGNC:59532
Macaca mulatta	ACSF2	VGNC	VGNC:69536
Mus musculus	ACSF2	MGD	MGI:2388287
Canis familiaris	ACSF2	VGNC	VGNC:37530
Rattus norvegicus	ACSF2	RGD	RGD:1562656
Others	ACSF2	NCBI