CUL1 - cullin 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8454

About CUL1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:148,697,756-148,801,110 (from NCBI)

This gene has 17 transcripts (splice variants), 249 orthologues and 7 paralogues. Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin Ligase complex and SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL1 Products (6)

mRNA	Protein	Name
NM_001370660.1	NP_001357589.1	cullin-1
NM_001370661.1	NP_001357590.1	cullin-1
NM_001370662.1	NP_001357591.1	cullin-1
NM_001370663.1	NP_001357592.1	cullin-1
NM_001370664.1	NP_001357593.1	cullin-1
NM_003592.3	NP_003583.2	cullin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11961546	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	10644755	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	11961546	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11961546	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10644755	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10644755	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	15145941	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15103331	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Parkin-FBXW7-Cul1 ubiquitin ligase complex	IPI IPI: Inferred from physical interaction	12628165	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	11956208	GOA
part of cullin-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	22405651	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19617556	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL1 Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
776 a.a.

Protein Preferred Names	Protein Names
cullin-1	CUL-1

CUL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CUL1	Q13616	UBE2M	Homo sapiens	P61081	Enzymatic Study	17914462
Intra	CUL1	Q13616	UBE2M	Homo sapiens	P61081	X-Ray Diffraction	24949976
Intra	CUL1	Q13616	CCNY	Homo sapiens	Q8ND76	Anti Tag CoIP	24794231
Cross	CUL1	Q13616	UBC12	Saccharomyces cerevisiae	P52491	Crosslink	21765416
Intra	CUL1	Q13616	FBXO3	Homo sapiens	Q9UK99	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	FBXO3	Homo sapiens	Q9UK99	TAP	21145461
Intra	CUL1	Q13616	FBXO22	Homo sapiens	Q8NEZ5	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	FBXO22	Homo sapiens	Q8NEZ5	Anti Tag CoIP	21145461
Intra	CUL1	Q13616	FBXO17	Homo sapiens	Q96EF6	TAP	21145461
Intra	CUL1	Q13616	FBXO17	Homo sapiens	Q96EF6	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	ARIH1	Homo sapiens	Q9Y4X5	TAP	21145461
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	CoIP	12609982
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	CoIP	14603323
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	TAP	21145461
Intra	CUL1	Q13616	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	17318178
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Tag CoIP	21145461
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	CoIP	12609982
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	17290223
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	Anti Bait CoIP	14685242
Intra	CUL1	Q13616	SKP1	Homo sapiens	P63208	TAP	21145461
Intra	CUL1	Q13616	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	CUL1	Q13616	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL1	Q13616	YBX1	Homo sapiens	P67809	TAP	21145461
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	CoIP	14603323
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	PLA	25241761
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	CoIP	10644755
Intra	CUL1	Q13616	FBXW11	Homo sapiens	Q9UKB1	TAP	21145461
Intra	CUL1	Q13616	FBXW7	Homo sapiens	Q969H0	CoIP	14603323
Intra	CUL1	Q13616	FBXW7	Homo sapiens	Q969H0	TAP	21145461
Intra	CUL1	Q13616	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
Intra	CUL1	Q13616	FBXO6	Homo sapiens	Q9NRD1	Anti Tag CoIP	23108047
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Solution Sedimentation	21765416
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	SAXS	18805092
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	X-Ray Diffraction	11961546
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Pull Down	20399188
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Crosslink	18805092
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	GMS	20399188
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	X-Ray Diffraction	24949976
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	Pull Down	11961546
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	X-Ray Diffraction	21765416
Intra	CUL1	Q13616	RBX1	Homo sapiens	P62877	CoIP	12609982
Intra	CUL1	Q13616	CAND1	Homo sapiens	Q86VP6	CoIP	12609982
Intra	CUL1	Q13616	CAND1	Homo sapiens	Q86VP6	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	CAND1	Homo sapiens	Q86VP6	Pull Down	16861300
Intra	CUL1	Q13616	SKP2	Homo sapiens	Q13309	Anti Bait CoIP	12504026
Intra	CUL1	Q13616	SKP2	Homo sapiens	Q13309	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	SKP2	Homo sapiens	Q13309	TAP	21145461
Intra	CUL1	Q13616	CDKN1B	Homo sapiens	P46527	Pull Down	11961546
Cross	CUL1	Q13616	Fbxl21	Mus musculus	Q8BFZ4	BiFC	23452855
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Anti Bait CoIP	21145461
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Comigration in SDS	21765416
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	TAP	21145461
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Comigration in SDS	18723677
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	X-Ray Diffraction	24949976
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	Anti Tag CoIP	18723677
Intra	CUL1	Q13616	NEDD8	Homo sapiens	Q15843	SAXS	18805092
Intra	CUL1	Q13616	FBXO33	Homo sapiens	Q7Z6M2	TAP	21145461
Intra	CUL1	Q13616	FBXW2	Homo sapiens	Q9UKT8	Anti Tag CoIP	23108047
Intra	CUL1	Q13616	FBXW2	Homo sapiens	Q9UKT8	TAP	21145461
Intra	CUL1	Q13616	FBXW2	Homo sapiens	Q9UKT8	CoIP	14603323
Intra	CUL1	Q13616	FBXO4	Homo sapiens	Q9UKT5	Anti Tag CoIP	23108047
Intra	CUL1	Q13616	CDC34	Homo sapiens	P49427	Crosslink	19945379
Cross	CUL1	Q13616	m005R	Myxoma virus	Q83730	Anti Tag CoIP	16051867

Cross: Cross-species interaction Intra: Intraspecies interaction

CUL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82633	Cullin 1 Antibody (YA2378)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Vaccinia
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Invasive Bladder Transitional Cell Carcinoma	Invasive Bladder Urothelial Carcinoma Infiltrating Bladder Urothelial Carcinoma
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112134	CSN5i-3	Inhibitor	99.95%	Unkown
HY-148602	KH-4-43	Inhibitor	99.72%	Unkown
HY-RS03359	CUL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-159601	CSN5-IN-1	Inhibitor	/	Unkown
HY-162240	SJH1-51B	Degrader	/	Unkown
HY-181795	CSN5-IN-3		/	Unkown
HY-RS21318	Cul1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27837	Cul1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CUL1	VGNC	VGNC:71565
Felis catus	CUL1	VGNC	VGNC:61282
Mus musculus	CUL1	MGD	MGI:1349658
Canis familiaris	CUL1	VGNC	VGNC:39728
Bos taurus	CUL1	VGNC	VGNC:55747
Rattus norvegicus	CUL1	RGD	RGD:1308157
Others	CUL1	NCBI