FBXO3 - F-box protein 3 Gene

Also Known as FBA; FBX3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26273

About FBXO3

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:33,740,944-33,774,520 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.3), kidney (RPKM 10.4) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]

FBXO3 Products (2)

mRNA Protein Name
NM_012175.4 NP_036307.2 F-box only protein 3 isoform 1
NM_033406.4 NP_208385.1 F-box only protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
26037928 GOA
Biological Process GO Annotation Evidence References Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
26037928 GOA
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
26037928 GOA
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
26037928 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO3 Protein Structure

F-box-like

F-box-like: F-box-like (14 - 58)

SMI1_KNR4

SMI1_KNR4: SMI1 / KNR4 family (SUKH-1) (122 - 249)

DUF525

DUF525: ApaG domain (294 - 383)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

F-box only protein 3

  • F-box protein FBX3

FBXO3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO3 Q9UK99 SKP1 Homo sapiens P63208
Y2H
21516116
Intra
FBXO3 Q9UK99 SKP1 Homo sapiens P63208
Anti Tag CoIP
22632967
Intra
FBXO3 Q9UK99 SKP1 Homo sapiens P63208
Y2H Prey Pooling
32296183
Intra
FBXO3 Q9UK99 SKP1 Homo sapiens P63208
Anti Tag CoIP
33961781
Intra
FBXO3 Q9UK99 SKP1 Homo sapiens P63208
Y2H Array
32296183
Intra
FBXO3 Q9UK99 CUL1 Homo sapiens Q13616
Anti Tag CoIP
33961781
Intra
FBXO3 Q9UK99 CUL1 Homo sapiens Q13616
Anti Tag CoIP
21145461
Cross
FBXO3 Q9UK99 tat Human immunodeficiency virus P04608
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

FBXO3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86876 FBXO3 Antibody (YA6569) WB Human, Mouse

Related Diseases

Diseases Alias
Rift Valley Fever

  • Rfv - [Rift Valley Fever]
3-Methylglutaconic Aciduria, Type I

  • 3-Methylglutaconyl-Coa Hydratase Deficiency

  • 3-Methylglutaconic Aciduria Type 1

  • Mga1

  • MGCA1

  • 3mg-Coa Hydratase Deficiency

  • Mga Type I

  • Mga, Type I

  • 3-Mg-Coa-Hydratase Deficiency

  • 3 Methylglutaconyl Coa Hydratase Deficiency

  • 3-Methylglutaconic Aciduria Type I

  • 3 Alpha Methylglutaconic Aciduria Type I

  • 3 Methylglutaconic Aciduria Type 1

  • 3-Mgca Type I

  • 3mg Coa Hydratase Deficiency

  • Auh Defect

  • Primary 3-Methylglutaconic Aciduria

  • 3-Methylglutaconic Aciduria 1

  • 3-Alpha-Methylglutaconic Aciduria Type 1

  • 3-Alpha-Methylglutaconyl-Coa Hydratase Deficiency

  • 3-@Methylglutaconic Aciduria, Type I

  • Megaloblastic Anemia Due To Inborn Errors Of Metabolism
Congenital Bile Acid Synthesis Defect

  • 3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency

  • Cba

  • Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency

  • Basd

  • Bile Acid Synthesis Defect, Congenital, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117937 BC-1215 Inhibitor 99.94% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FBXO3 RGD RGD:1593433
Felis catus FBXO3 VGNC VGNC:62184
Bos taurus FBXO3 VGNC VGNC:28902
Mus musculus FBXO3 MGD MGI:1929084
Macaca mulatta FBXO3 VGNC VGNC:72487
Canis familiaris FBXO3 VGNC VGNC:40771
Others FBXO3 NCBI