Fbxl21 - F-box and leucine-rich repeat protein 21 Gene

Also Known as FBL3B; Psttm; FBXL3B; D630045D17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 213311

Summary

Involved in entrainment of circadian clock by photoperiod and protein ubiquitination. Located in cytosol and nucleus. Part of SCF ubiquitin Ligase complex. Is expressed in gonad; metanephros; nervous system; and stomach. Orthologous to human FBXL21P (F-box and leucine rich repeat protein 21, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Low expression observed in reference dataset.

Fbxl21 Products (3)

mRNA Protein Name
NM_001346732.1 NP_001333661.1 F-box/LRR-repeat protein 21 isoform 2
NM_001359807.1 NP_001346736.1 F-box/LRR-repeat protein 21 isoform 3
NM_178674.5 NP_848789.2 F-box/LRR-repeat protein 21 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23452855 MGI
Biological Process GO Annotation Evidence References Source
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
23452855 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23452855 MGI
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
23452855 MGI
located in cytosol IDA
IDA: Inferred from direct assay
23452855 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23452855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fbxl21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fbxl21 Q8BFZ4 Cry1 Mus musculus P97784
Anti Tag CoIP
23452855
Intra
Fbxl21 Q8BFZ4 Cry1 Mus musculus P97784
Anti Bait CoIP
23452855
Intra
Fbxl21 Q8BFZ4 Cry1 Mus musculus P97784
Anti Tag CoIP
23452856
Intra
Fbxl21 Q8BFZ4 Cry2 Mus musculus Q9R194
Anti Bait CoIP
23452855
Intra
Fbxl21 Q8BFZ4 Cry2 Mus musculus Q9R194
Anti Tag CoIP
23452856
Cross
Fbxl21 Q8BFZ4 SKP1 Homo sapiens P63208
Anti Tag CoIP
23452856
Cross
Fbxl21 Q8BFZ4 CUL1 Homo sapiens Q13616
Anti Tag CoIP
23452856
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04798 FBXO21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04783 FBXL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04789 FBXL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04790 FBXL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18815 Fbxl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25305 Fbxl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown