CD49e/Integrin alpha-5
CD49e is the integrin alpha-5 chain, which pairs exclusively with beta-1 (CD29) to form the fibronectin receptor VLA-5 (α5β1). The alpha-5 subunit binds the RGD motif within the central cell-binding domain of fibronectin, mediating cell attachment, spreading, and migration on fibronectin matrices. Beyond adhesion, α5β1 drives fibronectin fibril assembly and is essential for embryonic development, with loss of ITGA5 causing early embryonic lethality in mice. The receptor is expressed broadly on fibroblasts, endothelial and epithelial cells, and most leukocytes, including monocytes and dendritic cells. Dysregulated α5β1 signaling contributes to tumor progression, fibrosis, and impaired wound repair.
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CD49e/Integrin alpha-5 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
