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Cat. No.: HY-168222

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Thalidomide-PEG1-OTs

Thalidomide-PEG1-OTs (Compound 5) is a ligand for E3 ligase, used for the synthesis of YD54 (HY-168221) .

For research use only. We do not sell to patients.

CAS No.: 2850354-04-8
Formula: C₂₂H₂₀N₂O₈S
Molecular Weight:472.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Thalidomide-PEG1-OTs Chemical Structure

CAS No.: 2850354-04-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Thalidomide-PEG1-OTs (Compound 5) is a ligand for E3 ligase, used for the synthesis of YD54 (HY-168221) ^[1].

IC₅₀ & Target

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2850354-04-8
Molecular Weight 472.47
Formula C₂₂H₂₀N₂O₈S
SMILES

O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3OCCOS(C4=CC=C(C)C=C4)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kotagiri S, et al. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Thalidomide-PEG1-OTs

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thalidomide-PEG1-OTs Related Classifications

HY-168222 Related Classifications