SBE-β-CD
(Synonyms: Sulfobutylether-β-Cyclodextrin)
166 Cited Publications
Customer Review
Based on 166 publication(s) in Google Scholar
SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 182410-00-0
- Molecular Weight:2083-2257
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) SBE-β-CD
More- Nature. 2026 Mar;651(8104):231-241. [Abstract]
- Nature. 2025 Jan;637(8044):184-194. [Abstract]
- Cancer Cell. 2020 Dec 14;38(6):844-856.e7. [Abstract]
- Nat Med. 2017 Jun;23(6):723-732. [Abstract]
- Cell. 2021 Jul 22;184(15):4032-4047.e31. [Abstract]
- Immunity. 2026 May 12;59(5):1398-1421.e20. [Abstract]
- Immunity. 2025 May 22:S1074-7613(25)00221-3. [Abstract]
- Cancer Discov. 2025 Jan 13;15(1):162-178. [Abstract]
- Nat Immunol. 2026 Jan;27(1):110-125. [Abstract]
- Cell Stem Cell. 2024 Oct 3;31(10):1484-1500.e9. [Abstract]
- Cancer Res. 2017 Jan 15;77(2):579-589. [Abstract]
- Nat Microbiol. 2026 Jun;11(6):1677-1695. [Abstract]
- Nat Commun. 2026 Feb 25;17(1):3142. [Abstract]
- Nat Commun. 2025 Sep 17;16(1):8287. [Abstract]
- Nat Commun. 2024 Oct 8;15(1):8723. [Abstract]
- Nat Commun. 2024 Mar 16;15(1):2377. [Abstract]
- Nat Commun. 2024 Feb 14;15(1):1353. [Abstract]
- Nat Commun. 2023 Oct 18;14(1):6584. [Abstract]
- Nat Commun. 2019 Jul 1;10(1):2901. [Abstract]
- Nat Commun. 2018 Jun 29;9(1):2547. [Abstract]
- Metabolism. 2018 May:82:88-99. [Abstract]
- Sci Transl Med. 2021 Jan 20;13(577):eaba7401. [Abstract]
- Theranostics. 2022 May 27;12(10):4581-4598. [Abstract]
- Theranostics. 2019 Nov 26;9(26):8426-8436. [Abstract]
- J Clin Invest. 2025 Jun 2;135(11):e187490. [Abstract]
- J Exp Clin Cancer Res. 2024 Jul 24;43(1):205. [Abstract]
- J Exp Clin Cancer Res. 2021 Mar 26;40(1):113. [Abstract]
- Adv Sci (Weinh). 2026 Jun;13(34):e22891. [Abstract]
- Adv Sci (Weinh). 2025 Oct 5:e03576. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(32):e04467. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(13):e2417449. [Abstract]
- Adv Sci (Weinh). 2023 Jan;10(3):e2203718. [Abstract]
- Alzheimers Dement. 2025 Feb;21(2):e14518. [Abstract]
- Chem Eng J. 2025 Oct 8;524:169421.
- Cancer Lett. 2016 Oct 10;381(1):14-22. [Abstract]
- Phytomedicine. 2025 Sep:145:156951. [Abstract]
- Acta Pharmacol Sin. 2026 Jan 1. [Abstract]
- Cell Death Discov. 2021 Dec 4;7(1):374. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2426107122. [Abstract]
- BME Front. 2025 Dec 9:6:0207. [Abstract]
- Int J Biol Macromol. 2025 Jul 29;321(Pt 3):146394. [Abstract]
- Int J Nanomedicine. 2025 Jan 16:20:669-684. [Abstract]
- Int J Biol Macromol. 2024 Oct;277(Pt 1):134024. [Abstract]
- Mol Ther Oncol. 2025 Dec 9.
- Mol Med. 2026 Feb 28;32(1):32. [Abstract]
- Mol Med. 2025 Jun 11;31(1):234. [Abstract]
- Phytother Res. 2023 Feb;37(2):611-626. [Abstract]
- Cancer Immunol Res. 2026 May 28. [Abstract]
- Cancer Immunol Res. 2021 Jun;9(6):665-681. [Abstract]
- Br J Cancer. 2022 Sep;127(4):661-674. [Abstract]
- Cell Rep. 2025 Nov 18;44(12):116577. [Abstract]
- Cell Rep. 2023 Apr 15;42(4):112396. [Abstract]
- Cell Rep. 2020 Nov 17;33(7):108395. [Abstract]
- Cell Rep. 2019 Oct 8;29(2):249-257.e8. [Abstract]
- Cell Prolif. 2024 Dec;57(12):e13719. [Abstract]
- Transl Psychiatry. 2023 Oct 6;13(1):310. [Abstract]
- Br J Pharmacol. 2018 Jan;175(1):84-99. [Abstract]
- Cell Mol Neurobiol. 2026 Jun 19. [Abstract]
- Int J Radiat Oncol Biol Phys. 2025 Jun 16:S0360-3016(25)03903-3. [Abstract]
- Int J Oncol. 2017 Aug;51(2):425-434. [Abstract]
- Pharmaceutics. 2026 Jan 12;18(1):103. [Abstract]
- Pharmaceutics. 2025 Nov 27;17(12):1524. [Abstract]
- J Ethnopharmacol. 2026 Jun 24:371:122040. [Abstract]
- Ecotoxicol Environ Saf. 2024 Oct 1:284:116906. [Abstract]
- Cell Biosci. 2025 Apr 13;15(1):46. [Abstract]
- Mol Ther Nucleic Acids. 2022 Jul 20:29:538-549. [Abstract]
- Cell Mol Life Sci. 2021 Feb;78(4):1837-1851. [Abstract]
- Life Sci. 2025 Oct 15:379:123849. [Abstract]
- Life Sci. 2025 Aug 15:375:123744. [Abstract]
- RSC Adv. 2023 Sep 11;13(39):27244-27254. [Abstract]
- Neurobiol Dis. 2025 Sep:213:107020. [Abstract]
- Neurobiol Dis. 2022 Jun 15:168:105689. [Abstract]
- J Am Heart Assoc. 2021 Jul 20;10(14):e019877. [Abstract]
- Matrix Biol. 2023 Apr:118:69-91. [Abstract]
- Matrix Biol. 2022 Sep:112:171-189. [Abstract]
- Eur J Pharmacol. 2025 Mar 15:991:177329. [Abstract]
- J Affect Disord. 2024 Apr 1:350:761-773. [Abstract]
- Int Immunopharmacol. 2025 Oct 30:164:115384. [Abstract]
- Int Immunopharmacol. 2025 Jun 5:157:114796. [Abstract]
- Int Immunopharmacol. 2025 Mar 26:150:114278. [Abstract]
- Mol Neurobiol. 2025 Jan;62(1):1079-1093. [Abstract]
- Mucosal Immunol. 2021 Mar;14(2):500-510. [Abstract]
- Inflammation. 2025 Mar 1. [Abstract]
- Front Pharmacol. 2022 Jan 10;12:792263. [Abstract]
- Front Pharmacol. 2018 Jan 30:9:25. [Abstract]
- J Ovarian Res. 2023 Nov 28;16(1):231. [Abstract]
- ACS Omega. 2025 Dec 23.
- Molecules. 2023 May 15;28(10):4096. [Abstract]
- Sci Rep. 2026 May 4;16(1):20485. [Abstract]
- Sci Rep. 2026 Apr 20;16(1):12890. [Abstract]
- Sci Rep. 2023 May 11;13(1):7656. [Abstract]
- Cancer Sci. 2016 May;107(5):638-43. [Abstract]
- Int J Cancer. 2016 Feb 15;138(4):1024-32. [Abstract]
- Sci Rep. 2015 Oct 30:5:15881. [Abstract]
- Neuropharmacology. 2026 May 1:288:110833. [Abstract]
- Oncol Rep. 2019 Jan;41(1):447-454. [Abstract]
- J Neurochem. 2026 Jan;170(1):e70336. [Abstract]
- Acta Biochim Biophys Sin (Shanghai). 2026 Jul 13. [Abstract]
- iScience. 2025 Nov 19;28(12):114120. [Abstract]
- Neurochem Res. 2022 Dec;47(12):3777-3791. [Abstract]
- Lung. 2024 Nov 27;203(1):4. [Abstract]
- J Biol Chem. 2024 Nov;300(11):107848. [Abstract]
- Mol Immunol. 2026 Jul:195:186-197. [Abstract]
- Mol Immunol. 2022 Dec:152:55-66. [Abstract]
- PLoS Negl Trop Dis. 2017 Dec 28;11(12):e0006104. [Abstract]
- ChemMedChem. 2026 Mar 13;21(5):e202500744. [Abstract]
- BMC Pharmacol Toxicol. 2025 Jul 17;26(1):134. [Abstract]
- Cancer Prev Res. 2024 Oct 1;17(10):457-470. [Abstract]
- Comput Biol Chem. 2024 Oct:112:108111. [Abstract]
- Neuroscience. 2023 Sep 15:528:64-74. [Abstract]
- Cell Immunol. 2021 Aug:366:104384. [Abstract]
- Neuropsychiatr Dis Treat. 2022 May 16:18:1027-1037. [Abstract]
- J Pain Res. 2026 Jun 3:19:604818. [Abstract]
- Cereb Cortex. 2023 Jul 5;33(14):8858-8875. [Abstract]
- PeerJ. 2026 Apr 30:14:e21194. [Abstract]
- PLoS One. 2025 Feb 5;20(2):e0316952. [Abstract]
- PLoS One. 2024 Sep 19;19(9):e0310524. [Abstract]
- PLoS One. 2023 Sep 14;18(9):e0291537. [Abstract]
- Physiol Behav. 2025 Nov 1:301:115059. [Abstract]
- Clin Exp Pharmacol Physiol. 2025 Nov;52(11):e70072. [Abstract]
- Biochem Biophys Res Commun. 2018 Jun 18;501(1):9-15. [Abstract]
- Cancer Chemother Pharmacol. 2016 Mar;77(3):623-8. [Abstract]
- Biochem Biophys Res Commun. 2015 May 1;460(2):362-7. [Abstract]
- Biopharm Drug Dispos. 2018 Jan;39(1):30-37. [Abstract]
- Oncol Lett. 2024 Sep 24;28(6):560. [Abstract]
- Oncol Lett. 2017 Dec;14(6):6863-6868. [Abstract]
- Hematology. 2026 Dec 31;31(1):2691533. [Abstract]
- World Neurosurg. 2022 Feb:158:e856-e864. [Abstract]
- SSRN. 2026 Jun 23.
- medRxiv. 2026 May 6:2026.05.05.26352474. [Abstract]
- SSRN. 2026 May 21.
- bioRxiv. 2026 May 21:2026.05.19.726175. [Abstract]
- bioRxiv. 2026 Apr 8:2026.04.05.713683. [Abstract]
- bioRxiv. 2026 Mar 30:2026.03.26.714605. [Abstract]
- bioRxiv. 2026 Mar 6.
- J Mol Liq. 2026 Feb 15.
- bioRxiv. 2025 Oct 6.
- bioRxiv. 2025 Sep 3:2025.08.30.673282. [Abstract]
- ALA-Porphyrin Science. 2025.
- bioRxiv. 2025 Jun 12:2025.06.10.656791. [Abstract]
- Patent. US20250144040A1.
- bioRxiv. 2025 March 14.
- Guidelines and Standards in Chinese Medicine. 2024 Dec.
- Res Sq. 2024 Jul 12.
- SSRN. 2024 Jun 19.
- biorxiv. 2024 Jun 05.
- bioRxiv. 2024 Jun 28:2024.06.23.600305. [Abstract]
- bioRxiv. 2024 Apr 12.
- bioRxiv. 2024 Mar 25:2024.03.21.586157. [Abstract]
- Res Sq. 2024 Feb 22:rs.3.rs-3959342. [Abstract]
- bioRxiv. 2023 Oct 1:2023.09.29.560194. [Abstract]
- bioRxiv. 2023 Oct 10.
- bioRxiv. 2023 Sep 16:2023.09.15.554413. [Abstract]
- Research Square Preprint. 2023 Sep 18.
- University of Ottawa. 2023 Jun 12.
- Oxid Med Cell Longev. 2022 Dec 7:2022:3373828. [Abstract]
- Patent. US20220380473A1.
- J Mol Liq. 9 September 2022, 120314.
- Research Square Print. 2022 Jun.
- Research Square Preprint. 2022 May.
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- University of Cambridge. 2021 , e20.
- ETH Zurich. 2021 Apr.
- Patent. US20200385396A1.
- Patent. US20170290918A1.
- University of Chile. 2017.
Biological Activity
Description
SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents[1].
In Vitro
SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 182410-00-0
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Appearance Solid
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Molecular Weight 2083-2257
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Color White to off-white
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SMILES
[R]O[C@@H]1[C@H](O[R])[C@H](O[C@@H]2[C@H](O[R])C(O[R])[C@H](O3)[C@@H](CO[R])O2)[C@@H](CO[R])O[C@@H]1O[C@H]4[C@H](O[R])[C@@H](O[R])[C@@H](O[C@H]5[C@H](O[R])[C@@H](O[R])[C@@H](O[C@@H]6C(O[R])[C@H](O[R])[C@H](O[C@@H]7[C@@H](O[R])[C@H](O[R])[C@H](O[C@@H]8[C@@H](O[R])[C@H](O[R])[C@H]3O[C@H]8CO[R])O[C@H]7CO[R])O[C@H]6CO[R])O[C@@H]5CO[R])O[C@@H]4CO[R].[R= H 21-m or C4H8SO3-Na+ m , m=6.0-7.1]
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Synonyms
Sulfobutylether-β-Cyclodextrin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (166)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Nature
2026 Mar;651(8104):231-241. PMID: 41565826 -
Nature
2025 Jan;637(8044):184-194. PMID: 39633048 -
Cancer Cell
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. [Abstract]2020 Dec 14;38(6):844-856.e7. PMID: 33186520 -
Nat Med
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. [Abstract]2017 Jun;23(6):723-732. PMID: 28394332 -
Cell
2021 Jul 22;184(15):4032-4047.e31. PMID: 34171309 -
Immunity
2026 May 12;59(5):1398-1421.e20. PMID: 41956098 -
Immunity
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis. [Abstract]2025 May 22:S1074-7613(25)00221-3. PMID: 40449484 -
Cancer Discov
Combined KRAS Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous PDAC Model. [Abstract]2025 Jan 13;15(1):162-178. PMID: 39348506 -
Nat Immunol
Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease. [Abstract]2026 Jan;27(1):110-125. PMID: 41461986 -
Cell Stem Cell
Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]2024 Oct 3;31(10):1484-1500.e9. PMID: 39181130 -
Cancer Res
SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. [Abstract]2017 Jan 15;77(2):579-589. PMID: 27671677 -
Nat Microbiol
Lipid accumulation in tuberculosis granulomas inhibits macrophage-CD4+ T cell interactions and infection control. [Abstract]2026 Jun;11(6):1677-1695. PMID: 41933199 -
Nat Commun
Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer. [Abstract]2026 Feb 25;17(1):3142. PMID: 41735312 -
Nat Commun
RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity. [Abstract]2025 Sep 17;16(1):8287. PMID: 40962798 -
Nat Commun
A germline-to-soma signal triggers an age-related decline of mitochondrial stress response. [Abstract]2024 Oct 8;15(1):8723. PMID: 39379393 -
Nat Commun
2024 Mar 16;15(1):2377. PMID: 38493213 -
Nat Commun
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification. [Abstract]2024 Feb 14;15(1):1353. PMID: 38355624 -
Nat Commun
Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis. [Abstract]2023 Oct 18;14(1):6584. PMID: 37852976 -
Nat Commun
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. [Abstract]2019 Jul 1;10(1):2901. PMID: 31263101 -
Nat Commun
Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program. [Abstract]2018 Jun 29;9(1):2547. PMID: 29959321 -
Metabolism
Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus. [Abstract]2018 May:82:88-99. PMID: 29366755 -
Sci Transl Med
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. [Abstract]2021 Jan 20;13(577):eaba7401. PMID: 33472956 -
Theranostics
Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal. [Abstract]2022 May 27;12(10):4581-4598. PMID: 35832081 -
Theranostics
Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy. [Abstract]2019 Nov 26;9(26):8426-8436. PMID: 31879528 -
J Clin Invest
2025 Jun 2;135(11):e187490. PMID: 40454483 -
J Exp Clin Cancer Res
Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia. [Abstract]2024 Jul 24;43(1):205. PMID: 39044280 -
J Exp Clin Cancer Res
Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma. [Abstract]2021 Mar 26;40(1):113. PMID: 33771199 -
Adv Sci (Weinh)
SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury. [Abstract]2026 Jun;13(34):e22891. PMID: 41904943 -
Adv Sci (Weinh)
2025 Oct 5:e03576. PMID: 41047470 -
Adv Sci (Weinh)
A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats. [Abstract]2025 Aug;12(32):e04467. PMID: 40448603 -
Adv Sci (Weinh)
Hybrid Electro-optical Stimulation Improves Ischemic Brain Damage by Augmenting the Glymphatic System. [Abstract]2025 Apr;12(13):e2417449. PMID: 39927473 -
Adv Sci (Weinh)
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity. [Abstract]2023 Jan;10(3):e2203718. PMID: 36445063 -
Alzheimers Dement
Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function. [Abstract]2025 Feb;21(2):e14518. PMID: 39887820 -
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Cancer Lett
A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis. [Abstract]2016 Oct 10;381(1):14-22. PMID: 27424523 -
Phytomedicine
Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration. [Abstract]2025 Sep:145:156951. PMID: 40527062 -
Acta Pharmacol Sin
A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts. [Abstract]2026 Jan 1. PMID: 41478880 -
Cell Death Discov
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis. [Abstract]2021 Dec 4;7(1):374. PMID: 34864819 -
Proc Natl Acad Sci U S A
Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy. [Abstract]2025 Mar 25;122(12):e2426107122. PMID: 40106355 -
BME Front
Quantifying Spatiotemporal Heterogeneity of Tumor Metabolism and Vasculature with a Multiparametric Point-of-Investigation Microscope. [Abstract]2025 Dec 9:6:0207. PMID: 41377143 -
Int J Biol Macromol
Exploiting an evolutionary constraint: Targeting TatD nuclease with chrysosplenol D disrupts Mycoplasma gallisepticum infection. [Abstract]2025 Jul 29;321(Pt 3):146394. PMID: 40744178 -
Int J Nanomedicine
Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2. [Abstract]2025 Jan 16:20:669-684. PMID: 39835181 -
Int J Biol Macromol
Jun and JunB members of the AP-1 complex are potential therapeutic targets for silicosis. [Abstract]2024 Oct;277(Pt 1):134024. PMID: 39032899 -
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Mol Med
Correction: Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2. [Abstract]2026 Feb 28;32(1):32. PMID: 41764431 -
Mol Med
Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2. [Abstract]2025 Jun 11;31(1):234. PMID: 40500698 -
Phytother Res
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease. [Abstract]2023 Feb;37(2):611-626. PMID: 36325883 -
Cancer Immunol Res
Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer. [Abstract]2026 May 28. PMID: 42207977 -
Cancer Immunol Res
Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer. [Abstract]2021 Jun;9(6):665-681. PMID: 33839687 -
Br J Cancer
Targeting epidermal growth factor receptor in paclitaxel-resistant human breast and lung cancer cells with upregulated glucose-6-phosphate dehydrogenase. [Abstract]2022 Sep;127(4):661-674. PMID: 35597872 -
Cell Rep
Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG. [Abstract]2025 Nov 18;44(12):116577. PMID: 41259203 -
Cell Rep
2023 Apr 15;42(4):112396. PMID: 37061917 -
Cell Rep
Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. [Abstract]2020 Nov 17;33(7):108395. PMID: 33207205 -
Cell Rep
2019 Oct 8;29(2):249-257.e8. PMID: 31597089 -
Cell Prolif
Cellular senescence mediates retinal ganglion cell survival regulation post-optic nerve crush injury. [Abstract]2024 Dec;57(12):e13719. PMID: 39021340 -
Transl Psychiatry
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. [Abstract]2023 Oct 6;13(1):310. PMID: 37802998 -
Br J Pharmacol
Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis. [Abstract]2018 Jan;175(1):84-99. PMID: 29053877 -
Cell Mol Neurobiol
Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury. [Abstract]2026 Jun 19. PMID: 42321551 -
Int J Radiat Oncol Biol Phys
2025 Jun 16:S0360-3016(25)03903-3. PMID: 40532892 -
Int J Oncol
Bevacizumab counteracts VEGF-dependent resistance to erlotinib in an EGFR-mutated NSCLC xenograft model. [Abstract]2017 Aug;51(2):425-434. PMID: 28627678 -
Pharmaceutics
The Activity of FDA-Approved Prodrug Isavuconazonium Sulfate and Its Major Metabolite Isavuconazole Against Naegleria fowleri. [Abstract]2026 Jan 12;18(1):103. PMID: 41599210 -
Pharmaceutics
CC-90009, a Cereblon E3 Ligase Modulator, Exhibits Antiviral Efficacy Against JEV In Vitro and In Vivo via Targeted Degradation of GSPT1 and Viral NS5 Protein. [Abstract]2025 Nov 27;17(12):1524. PMID: 41471039 -
J Ethnopharmacol
Liquiritin prevents preterm labor by remodeling decidual steroid homeostasis through 11β-HSD1 inhibition. [Abstract]2026 Jun 24:371:122040. PMID: 42341859 -
Ecotoxicol Environ Saf
Calcitriol alleviates noise-induced hearing loss by regulating the ATF3/DUSP1 signalling pathway. [Abstract]2024 Oct 1:284:116906. PMID: 39182283 -
Cell Biosci
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8. [Abstract]2025 Apr 13;15(1):46. PMID: 40223119 -
Mol Ther Nucleic Acids
2022 Jul 20:29:538-549. PMID: 36035756 -
Cell Mol Life Sci
Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas. [Abstract]2021 Feb;78(4):1837-1851. PMID: 32851475 -
Life Sci
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Life Sci
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Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
View the Complete Stock Solution Preparation Table
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact
Protocol
Animal Administration[2]
Rats[2]
A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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Data Sheet (293 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28;350(1-2):188-196 [Content Brief]
[2]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67 [Content Brief]
Calculators
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SBE-β-CD Related Classifications
HY-17031 Related Classifications
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