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Cat. No.: HY-101773

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c-Met-IN-2

c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC₅₀ of 0.6 nM, with antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 1635406-73-3
Formula: C₂₄H₂₁FN₁₀O
Molecular Weight:484.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

c-Met-IN-2 Chemical Structure

CAS No.: 1635406-73-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC₅₀ of 0.6 nM, with antitumor activity.

IC₅₀ & Target

IC50: 0.6 nM (c-Met)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1993	IC₅₀	0.6 nM Compound: 14-2; Enantiomer-2	Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
NCI-H1993	IC₅₀	0.7 nM Compound: 14-1; Enantiomer-1	Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
NCI-H1993	IC₅₀	1.1 nM Compound: 14	Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
SNU-5	IC₅₀	0.6 nM Compound: 14-2; Enantiomer-2	Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
SNU-5	IC₅₀	0.8 nM Compound: 14-1; Enantiomer-1	Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]
SNU-5	IC₅₀	2 nM Compound: 14	Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay Growth inhibition of human SNU5 cells after 72 hrs by CCK-8 assay	[PMID: 28411455]

In Vitro

c-Met-IN-2 (Compound 14) is a potent and selective c-Met inhibitor, with an IC₅₀ of 0.6 nM. c-Met-IN-2 also shows weak activity on other kinases, with IC₅₀s of 1075 nM (AxI), 731 nM (RON), 18364 nM (VEGFR2), 5396 nM (c-Kit), 2357 nM (PDGFRa), 17056 nM (c-Src).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

c-Met-IN-2 (0.1, 1, 10 mg/kg, p.o., once daily) significantly reduces the volume of tumor in mice bearing H1993 tumors, and has similar effect in SNU-5 xenograft model via oral administration at 0.3, 1 and 3 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

Chemical Information

CAS No. 1635406-73-3
Molecular Weight 484.49
Formula C₂₄H₂₁FN₁₀O
SMILES

OCCN1N=CC(C2=CN=C3C(N(C(C4=C(F)C=C(N=CC(C5=CN(C)N=C5)=C6)C6=C4)C)N=N3)=N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao F, et al. Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural opt [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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