AGMO - alkylglycerol monooxygenase Gene

Also Known as TMEM195

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 392636

About AGMO

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:15,117,223-15,562,015 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Biased expression in liver (RPKM 8.7), small intestine (RPKM 2.1) and 4 other tissues.

Summary

The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent Enzymes. Variations in this gene have been associated with decreased glucose-stimulated Insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]

AGMO Products (1)

mRNA	Protein	Name
NM_001004320.2	NP_001004320.1	alkylglycerol monooxygenase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glyceryl-ether monooxygenase activity	IDA IDA: Inferred from direct assay	20643956	GOA
enables iron ion binding	IMP IMP: Inferred from mutant phenotype	20643956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ether lipid metabolic process	IDA IDA: Inferred from direct assay	20643956	GOA
involved in membrane lipid metabolic process	IDA IDA: Inferred from direct assay	20643956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20643956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGMO Protein Structure

FA_hydroxylase

0
100
200
300
400
445 a.a.

Protein Preferred Names	Protein Names
alkylglycerol monooxygenase	glyceryl-ether monooxygenase

AGMO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGMO	Q6ZNB7	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	AGMO	Q6ZNB7	AQP6	Homo sapiens	Q13520	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency	Sepiapterin Reductase Deficiency Spr Deficiency Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency Srd Drd Due To Srd Dopa-Responsive Hypersomnia Dyt-Spr Dyt/Park-Spr Sr-Deficient Drd Autosomal Recessive Sepiapterin Reductase-Deficient Drd Spr DRDSPRD Motor And Cognitive Disorder Due To Sepiapterin Reductase Deficiency Psychomotor Disorders
Sjogren-Larsson Syndrome	Sjögren-Larsson Syndrome SLS Faldh Deficiency Fatty Aldehyde Dehydrogenase Deficiency Fatty Acid Alcohol Oxidoreductase Deficiency Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia Sjogren Larsson Syndrome Fatty Alcohol:Nad+ Oxidoreductase Deficiency Sjogren-Larsson'S Syndrome Fadh Deficiency Fao Deficiency Congenital Icthyosis Mental Retardation Spasticity Syndrome Ichthyosis Oligophrenia Syndrome Sjoegren-Larsson Syndrome
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00451	AGMO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22097	Agmo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AGMO	VGNC	VGNC:37706
Bos taurus	AGMO	VGNC	VGNC:25731
Felis catus	AGMO	VGNC	VGNC:59684
Mus musculus	AGMO	MGD	MGI:2442495
Rattus norvegicus	AGMO	RGD	RGD:1312038
Macaca mulatta	AGMO	VGNC	VGNC:69754
Others	AGMO	NCBI