KEGIHAQ
KEGIHAQ is a novel signal peptide and an effector of the dipeptide transporter DppA. KEGIHAQ binds to the oligopeptide transporter OppA and inhibits OppA expression, which leads to compensatory up-regulation of DppA and thereby promotes dipeptide uptake. KEGIHAQ enhances the acid tolerance of bacteria by regulating the expression of transcriptional regulators rmal and spxA, thus promoting bacterial growth. KEGIHAQ can up-regulate genes related to amino acid metabolism to facilitate amino acid synthesis, energy production and various bacterial physiological activities. KEGIHAQ can serve as a nitrogen source-targeting peptide in high-density culture of lactic acid bacteria.
For research use only. We do not sell to patients.
- Formula: C33H55N11O11
- Molecular Weight:781.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DppA |
OppA |
KEGIHAQ (0.003-5 g/L; 12 h) potently promotes the proliferation of *Lactobacillus delbrueckii* subsp. *bulgaricus* sp1.1, with the optimal growth-promoting effect observed at a concentration of 0.1% (w/v), where the viable cell count reaches 1.34 × 109 CFU/mL[1].
KEGIHAQ (0.1% (w/v); 24 h) enhances the acid tolerance of *L. delbrueckii* subsp. *bulgaricus* sp1.1 under pH 4.2 conditions, and at a concentration of 0.1% (w/v), its viable cell count reaches 1.41 times that of the control group[1].
KEGIHAQ (0.1% (w/v)) acts as an effector to trigger global adaptive reprogramming in L. delbrueckii subsp. bulgaricus sp1.1, upregulating dppA and amino acid metabolism genes, thereby enhancing dipeptide uptake, amino acid synthesis, energy production, and acid resistance, without being directly assimilated itself[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 781.86
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Formula C33H55N11O11
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Sequence
Lys-Glu-Gly-Ile-His-Ala-Gln
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Sequence Shortening
KEGIHAQ
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KEGIHAQ Related Classifications
HY-P11920 Related Classifications
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