A new anthracycline antibiotic, cinerubin R. Taxonomy, structural elucidation and biological activity

  • J Antibiot (Tokyo). 1992 Oct;45(10):1599-608. doi: 10.7164/antibiotics.45.1599.
M Nakata  1 ,  M Saito ,  Y Inouye ,  S Nakamura ,  Y Hayakawa ,  H Seto
Affiliations
  • 1. Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
PMID: 1473987 DOI: 10.7164/antibiotics.45.1599
Abstract

A novel anthracycline Antibiotic, cinerubin R, was isolated from the fermentation broth of Streptomyces eurythermus strain H1715MY2. The structure of cinerubin R was elucidated to be 4"-aculosyl-4'-rhodinosyl-7-rhodosaminyl-epsilon-py rromycinone. Cinerubin R was active against Gram-positive bacteria and inhibited the growth of divergent multi-drug-resistant cells to the same extent as their parental cells.

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