QLH-11811
QLH-11811 is a mutant-selective EGFR tyrosine kinase inhibitor. QLH-11811 reversibly inhibits EGFR-19del/T790M/C797S and EGFR-L858R/T790M/C797S tyrosine kinase activity (IC50 = 2.6 nM and 3.1 nM, respectively), thereby overcoming C797S-mediated drug resistance. QLH-11811 exhibits weaker inhibitory activity against wild-type EGFR than against mutant EGFR variants. QLH-11811 can be used for research on advanced non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2595202-02-9
- Formula: C29H31BrN9O3P
- Molecular Weight:664.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
QLH-11811 exhibits IC50 values of 2.6 nM and 3.1 nM against EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK in Ba/F3 cell lines, respectively, and an IC50 of 61 nM against wild-type EGFR; in A431 cell lines, its IC50 against wild-type EGFR was 440 nM, demonstrating selectivity for mutant EGFR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2595202-02-9
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Molecular Weight 664.49
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Formula C29H31BrN9O3P
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SMILES
CN1C=C(C=N1)C2=C(C=C(C(NC3=NC=C(C(NC4=CC=C5N=CC=NC5=C4P(C)(C)=O)=N3)Br)=C2)OC)N6CCOCC6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
QLH-11811 Related Classifications
HY-189681 Related Classifications
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