DPPE-PEG2000-Asp6

DPPE-PEG2000-Asp6 is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. Asp6 peptide: Targeting/functional ligand-the Asp6 peptide consists of six aspartic acid residues, exhibiting high affinity for bone tissue (especially hydroxyapatite in the bone matrix), enabling bone-targeted delivery.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.