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Cat. No.: HY-155510

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DprE1-IN-5

DprE1-IN-5 (Compound 10) is a DprE1 inhibitor. DprE1-IN-5 has anti-TB activity against Mtb H37Rv strain (MIC: 4 μM). DprE1-IN-5 also has antimycobacterial activity against drug-resistant strains. DprE1-IN-5 has high microsomal stability.

For research use only. We do not sell to patients.

CAS No.: 3052383-46-4
Formula: C₂₀H₁₉N₅O₂
Molecular Weight:361.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DprE1-IN-5 Chemical Structure

CAS No.: 3052383-46-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
H9c2	IC₅₀	>50 μM Compound: 10	Cytotoxicity against rat H9c2 cells assessed as cell viability incubated for 72 hrs by MTT spectrophotometric analysis Cytotoxicity against rat H9c2 cells assessed as cell viability incubated for 72 hrs by MTT spectrophotometric analysis	[PMID: 37421887]
HepG2	IC₅₀	>125 μM Compound: 10	Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay	[PMID: 37421887]
HepG2	IC₅₀	59.01 μM Compound: 10	Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT spectrophotometric analysis Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT spectrophotometric analysis	[PMID: 37421887]

Chemical Information

CAS No. 3052383-46-4
Molecular Weight 361.40
Formula C₂₀H₁₉N₅O₂
SMILES

O=C1NC(N2CCOCC2)=NC3=C1N(CC4=CC=C5C=CC=CC5=C4)C=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Finger V, et al. 2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1. Eur J Med Chem. 2023 Oct 5;258:115611. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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