DSPE-PEG5000-Cy5
DSPE-PEG5000-Cy5 is a fluorescently labeled PEGylated phospholipid. After intravenous injection, DSPE-PEG5000-Cy5 shows only extremely low fluorescence accumulation at tumor sites in orthotopic tumor-bearing mice, and can be used as a negative control for evaluating tumor accumulation of nanoparticles. DSPE-PEG5000-Cy5 can serve as a fluorescent marker to prepare Cy5-labeled NPs-DPPA and NPs-DPPA (C3F8) for pharmacokinetic and biodistribution studies in mice. DSPE-PEG5000-Cy5 is widely applicable to research in fields related to triple-negative breast cancer, hepatocellular carcinoma and so on.
For research use only. We do not sell to patients.
- Molecular Weight:5000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DSPE-PEG-Cy5 (2 mg; 30 min) can be used to coat SnSNPs via probe sonication, resulting in fluorescently labeled nanoparticles suitable for biological imaging studies[1].
DSPE-PEG-Cy5 functions as a fluorescent labeling agent for NPs-DPPA and NPs-DPPA(C3F8), enabling visualization and quantification of the nanoparticles in biological systems[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Free DSPE-PEG-Cy5 (MW 5000) (50 μg per mouse; i.v.; single dose) exhibits rapid blood clearance in healthy male BALB/c mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 4-6 weeks old)[2]
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Dosage:50 μg per mouse
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Administration:i.v.; single dose
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Result:Exhibited rapid blood clearance, with no detectable fluorescence remaining in blood samples by 4 hours post-injection.
Chemical Information
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Molecular Weight 5000 (Average)
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SMILES
O=C(CCCCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCCCC[N+]1=C(/C=C/C=C/C=C2C(C)(C)C(C=CC=C3)=C3N\2C)C(C)(C)C4=C1C=CC=C4)=O)=O)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Li Y, et al. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nat Commun. 2023;14(1):6973. Published 2023 Nov 1. [Content Brief]
[2]. Fang J, et al. Bioactive Nanotherapeutic Ultrasound Contrast Agent for Concurrent Breast Cancer Ultrasound Imaging and Treatment. Adv Healthc Mater. 2024;13(26):e2401436. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG5000-Cy5 Related Classifications
HY-W440913 Related Classifications
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- DSPE-PEG5000-Cy5
- Liposome
- Fluorescent Dye
- orthotopic tumor-bearing mice
- fluorescence imaging
- hepatocellular carcinoma
- nanoparticle tumor accumulation
- in vivo pharmacokinetic studies
- triple-negative breast cancer
- BALB/c mice
- BALB/cJ mice
- biological imaging studies
- biodistribution studies
- Inhibitor
- inhibitor
- inhibit