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  3. Liposome Fluorescent Dye
  4. DSPE-PEG5000-Cy5

DSPE-PEG-Cy5, MW 5000 is a fluorescently labeled PEGylated phospholipid with a molecular weight of 5000 Da. After intravenous injection, DSPE-PEG-Cy5, MW 5000 shows only extremely low fluorescence accumulation at tumor sites in orthotopic tumor-bearing mice, and can be used as a negative control for evaluating tumor accumulation of nanoparticles. DSPE-PEG-Cy5, MW 5000 can serve as a fluorescent marker to prepare Cy5-labeled NPs-DPPA and NPs-DPPA (C3F8) for pharmacokinetic and biodistribution studies in mice. DSPE-PEG-Cy5, MW 5000 is widely applicable to research in fields related to triple-negative breast cancer, hepatocellular carcinoma and so on.

For research use only. We do not sell to patients.

DSPE-PEG5000-Cy5

DSPE-PEG5000-Cy5 Chemical Structure

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DSPE-PEG5000-Cy5 Related Antibodies

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Description

DSPE-PEG-Cy5, MW 5000 is a fluorescently labeled PEGylated phospholipid with a molecular weight of 5000 Da. After intravenous injection, DSPE-PEG-Cy5, MW 5000 shows only extremely low fluorescence accumulation at tumor sites in orthotopic tumor-bearing mice, and can be used as a negative control for evaluating tumor accumulation of nanoparticles. DSPE-PEG-Cy5, MW 5000 can serve as a fluorescent marker to prepare Cy5-labeled NPs-DPPA and NPs-DPPA (C3F8) for pharmacokinetic and biodistribution studies in mice. DSPE-PEG-Cy5, MW 5000 is widely applicable to research in fields related to triple-negative breast cancer, hepatocellular carcinoma and so on[1][2].

In Vitro

DSPE-PEG-Cy5 (2 mg; 30 min) can be used to coat SnSNPs via probe sonication, resulting in fluorescently labeled nanoparticles suitable for biological imaging studies[1].
DSPE-PEG-Cy5 functions as a fluorescent labeling agent for NPs-DPPA and NPs-DPPA(C3F8), enabling visualization and quantification of the nanoparticles in biological systems[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DSPE-PEG5000-Cy5 Related Antibodies
In Vivo

Free DSPE-PEG-Cy5 (i.v.) exhibits minimal tumor accumulation in orthotopic triple-negative breast cancer-bearing BALB/cJ mice[1].
Free DSPE-PEG-Cy5 (MW 5000) (50 μg per mouse; i.v.; single dose) exhibits rapid blood clearance in healthy male BALB/c mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 4-6 weeks old)[2]
Dosage: 50 μg per mouse
Administration: i.v.; single dose
Result: Exhibited rapid blood clearance, with no detectable fluorescence remaining in blood samples by 4 hours post-injection.
Molecular Weight

5000 (Average)

SMILES

O=C(CCCCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCCCC[N+]1=C(/C=C/C=C/C=C2C(C)(C)C(C=CC=C3)=C3N\2C)C(C)(C)C4=C1C=CC=C4)=O)=O)=O.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DSPE-PEG5000-Cy5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSPE-PEG5000-Cy5LiposomeFluorescent Dyeorthotopic tumor-bearing micefluorescence imaginghepatocellular carcinomananoparticle tumor accumulationin vivo pharmacokinetic studiestriple-negative breast cancerBALB/c miceBALB/cJ micebiological imaging studiesbiodistribution studiesInhibitorinhibitorinhibit

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