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Cat. No.: HY-P11008

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DX-236

DX-236 is a macrocyclic peptide with a binding affinity of 1.9 µM to human serum albumin (HSA). DX-236 can fuse with HSV to prolong its circulation in vivo.

For research use only. We do not sell to patients.

Formula: C₁₆₄H₂₂₃N₄₁O₄₇S₂
Molecular Weight:3584.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DX-236 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DX-236 is a macrocyclic peptide with a binding affinity of 1.9 µM to human serum albumin (HSA). DX-236 can fuse with HSV to prolong its circulation in vivo^[1].

Chemical Information

Molecular Weight 3584.90
Formula C₁₆₄H₂₂₃N₄₁O₄₇S₂
Sequence

Ac-Ala-Glu-Gly-Thr-Gly-Asp-Phe-Trp-Phe-Cys-Asp-Arg-Ile-Ala-Trp-Tyr-Pro-Gln-His-Leu-Cys-Glu-Phe-Leu-Asp-Pro-Glu-Gly-Gly-Gly-Lys-NH2 (Disulfide bridge:Cys10-Cys21)
Sequence Shortening

Ac-AEGTGDFWFCDRIAWYPQHLCEFLDPEGGGK-NH2 (Disulfide bridge:Cys10-Cys21)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wong JYK, et al. Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo. Nat Commun. 2023 Sep 13;14(1):5654. doi: 10.1038/s41467-023-41427-y. Erratum in: Nat Commun. 2023 Nov 21;14(1):7587. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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