endo-BCN-PEG8-acid
endo-BCN-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG8-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2126805-02-3
- Formula: C30H51NO12
- Molecular Weight:617.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-135971
endo-BCN-PEG4-acidADC Linker -
HY-W035129
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endo-BCN-PEG8-NHS esterPROTAC Linker -
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endo-BCN-O-PNBPROTAC Linker -
HY-W096079
BCN-endo-PEG4-NHSADC Linker -
HY-W111141
BCN-OHBCN-TPP Probe Control -
HY-130557
endo-BCN-PEG2-acidPROTAC Linker -
HY-133439
BCN-PEG4-NHS esterPROTAC Linkers -
HY-140350
5-endo-BCN-pentanoic acidPROTAC Linkers -
HY-134734
BCN-exo-PEG7-maleimideADC Linker -
HY-140067
endo-BCN-PEG2-NHS esterPROTAC Linker -
HY-133406
exo BCN-O-PNBPROTAC Linker
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
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PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2126805-02-3
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Molecular Weight 617.73
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Formula C30H51NO12
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SMILES
O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
endo-BCN-PEG8-acid Related Classifications
HY-140065 Related Classifications
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