Chlovalicin
Chlovalicin is found in the strain of Sporothrix sp. FO-4649. In the presence of 0.2 U/mL IL-6, Chlovalicin inhibits the growth of L6-dependent MH60 cells with lC50 of 7.5 μM. Chlovalicin also inhibits the growth of B16 melanoma cells with lC50 of 38 μM. Chlovalicin also displays inhibitory activity on osteoclastogenesis.
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- CAS No.: 179799-38-3
- Formula: C16H25ClO5
- Molecular Weight:332.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 179799-38-3
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Molecular Weight 332.82
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Formula C16H25ClO5
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SMILES
O[C@@]1([C@@]2([C@H](O2)C/C=C(C)\C)C)[C@](O)(CCC([C@H]1OC)=O)CCl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Osteoclast differentiation from monocyte/macrophage precursors
Osteoclast differentiation is an in vitro induction assay in which monocyte/macrophage-lineage precursors are exposed to macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL), generating multinucleated osteoclasts that are commonly identified by tartrate-resistant acid phosphatase (TRAP) staining and functionally confirmed by resorption pits on dentin, bone, or mineralized substrates. M-CSF supports survival and expansion of osteoclast precursors, while RANKL binding to RANK drives osteoclast commitment, fusion, maturation, and resorptive function; osteoprotegerin inhibits this pathway by binding RANKL and preventing RANK activation. The main readouts are the number of TRAP-positive multinucleated cells, formation of F-actin rings, and resorbed surface area; TRAP-positive multinucleated cells indicate osteoclast differentiation, whereas pit formation on dentin, bone, or mineralized coating indicates functional bone-resorbing activity.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chlovalicin Related Classifications
HY-N14126 Related Classifications
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