LUF7346
Based on 1 Customer Validation
LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC50 of 35.6 ± 3.2 nM.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 1821638-40-7
- Formula: C20H15BrN2O3
- Molecular Weight:411.25
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Potassium Channel Compound Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Ion Channel Compound Library
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Allosteric Modulators (AMs) Compound Library
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
12 μM
Compound: 7f
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Induction of dissociation of [3H]-dofetilide from Kv11.1 channel (unknown origin) assessed as dissociation rate expressed in HEK293 cells after 1 hr
Induction of dissociation of [3H]-dofetilide from Kv11.1 channel (unknown origin) assessed as dissociation rate expressed in HEK293 cells after 1 hr
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[PMID: 26519929] |
Chemical Information
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CAS No. 1821638-40-7
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Appearance Solid
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Molecular Weight 411.25
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Formula C20H15BrN2O3
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Color White to off-white
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SMILES
O=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=CC=CC=C3Br)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (243.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4316 mL | 12.1581 mL | 24.3161 mL | 60.7903 mL |
| 5 mM | 0.4863 mL | 2.4316 mL | 4.8632 mL | 12.1581 mL | |
| 10 mM | 0.2432 mL | 1.2158 mL | 2.4316 mL | 6.0790 mL | |
| 15 mM | 0.1621 mL | 0.8105 mL | 1.6211 mL | 4.0527 mL | |
| 20 mM | 0.1216 mL | 0.6079 mL | 1.2158 mL | 3.0395 mL | |
| 25 mM | 0.0973 mL | 0.4863 mL | 0.9726 mL | 2.4316 mL | |
| 30 mM | 0.0811 mL | 0.4053 mL | 0.8105 mL | 2.0263 mL | |
| 40 mM | 0.0608 mL | 0.3040 mL | 0.6079 mL | 1.5198 mL | |
| 50 mM | 0.0486 mL | 0.2432 mL | 0.4863 mL | 1.2158 mL | |
| 60 mM | 0.0405 mL | 0.2026 mL | 0.4053 mL | 1.0132 mL | |
| 80 mM | 0.0304 mL | 0.1520 mL | 0.3040 mL | 0.7599 mL | |
| 100 mM | 0.0243 mL | 0.1216 mL | 0.2432 mL | 0.6079 mL |
LUF7346 Related Classifications
HY-120375 Related Classifications
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