AZ-008
AZ-008 is a PPI-stabilizing molecular glue that acts as a 14-3-3σ/p53T387 protein-protein interaction stabilizer. AZ-008 has potential for cancer research.
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- No. CAS: 2488429-67-8
- Fòrmula: C15H20N4O2S
- Peso molecular:320.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
14-3-3σ |
In Vitro
AZ-008 (2000 µM) binds the same 14-3-3σ pocket in the presence or absence of p53pT387 and increases the amount of 14-3-3σ/p53pT387 complex in solution as shown by TROSY-HSQC NMR[1].
AZ-008 (1 mM; 1 h) increases the binding of 14-3-3σ to the fluorescently labeled p53pT387 peptide in FP, consistent with a weak stabilizing effect[1].
AZ-008 (1 mM) stabilizes the binding of 14-3-3σ to the immobilized p53pT387 peptide in SPR, consistent with a weak stabilizing effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2488429-67-8
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Peso molecular 320.41
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Fòrmula C15H20N4O2S
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SMILES
CC(OC1=C2C(C=C(C(N)=N)S2)=C(C(NCCN)=O)C=C1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ-008 Related Classifications
HY-190159 Related Classifications
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