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Referencia número: HY-143688

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EDMPC

EDMPC is a cationic lipid that efficiently mediates the transmembrane and intracellular delivery of nucleic acids and proteins. EDMPC encapsulates nucleic acids through electrostatic interactions to form lipoplexes, thereby protecting nucleic acids from enzymatic degradation in vivo and effectively promoting their endocytosis and uptake by cells. EDMPC can be used in research on cystic fibrosis, melanoma, and breast cancer.

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No. CAS: 183283-19-4
Fòrmula: C₃₈H₇₇NO₈P⁺
Peso molecular:706.99

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

EDMPC Chemical Structure

No. CAS: 183283-19-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

In Vitro

EDMPC most effectively delivers GFP siRNA to breast cancer cells, and its activity is associated with high fusogenicity and HII phase induction^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 183283-19-4
Peso molecular 706.99
Fòrmula C₃₈H₇₇NO₈P⁺
SMILES

C[N+](C)(C)CCOP(OC[C@@H](COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O)(OCC)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Noone PG, et al. Safety and biological efficacy of a lipid–CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Molecular Therapy. 2000 Jan 1;1(1):105-14.

[2]. Ferrari S, et al. Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium. Gene therapy. 2001 Sep;8(18):1380-6.

[3]. Toyofuku K, et al. Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids. ACS applied materials & interfaces. 2023 Jul 19;15(28):33299-33308.

[4]. Zhang Y, et al. Lipids and Lipid Derivatives for RNA Delivery. Chemical reviews. 2021 Oct 27;121(20):12181-12277.

[5]. Cui L, et al. Macromolecule-Loaded Hybrid Extracellular Vesicles via Ionic Lipid-Based Post-Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy. Journal of extracellular biology. 2026 Mar;5(3):e70125.

[6]. Sarker MS, et al. Needle-free transdermal delivery of lipid-based ionic liquid-mediated laminarin-loaded solid-in-oil nanodispersion for enhanced antibody response. Chem Lett. 2026;55:upag127.

[7]. Lonez C, et al. Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways. Nanomedicine : nanotechnology, biology, and medicine. 2014 May;10(4):775-82.

[8]. Gorman CM, et al. Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC. Gene therapy. 1997 Sep;4(9):983-92. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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