2. Immunology/Inflammation
  3. Complement System
  4. Factor B-IN-5

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy.

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Factor B-IN-5

Factor B-IN-5 Estructura química

No. CAS : 1644670-23-4

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Descripciòn

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy[1].

In Vivo

Factor B-IN-5 (20 and 60 mg/kg; i.g.; twice daily; for 10 weeks) improves interstitial inflammation of renal tubules and reduces kidney damage in male diabetic db/db C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male diabetic db/db C57BL/6J mice (C57BL/6J-LepRdb/db) (6 weeks)[1]
Dosage: 20 and 60 mg/kg
Administration: Oral gavage (i.g.); twice daily for 10 weeks
Result: Significantly reduced the level of uACR.
Significantly improved renal tubulointerstitial fibrosis and atrophy.
Significantly reduced the thickness of glomerular basement membrane (GBM).
Reduced the expression of inflammatory markers Kim-1 and IL-1β.
Improved mitochondrial morphology and dynamics and upregulated the expression of Mfn2 and Prkn.
Might exert its effect by regulating CASP3 and DPP4.
Peso molecular

392.49

Fòrmula

C24H28N2O3
No. CAS
SMILES

CC1=CC(OC)=C(CN2CC[C@@H](C)C[C@H]2C3=CC=C(C(O)=O)C=C3)C4=C1NC=C4
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Room temperature in continental US; may vary elsewhere.
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Pureza y Documentación
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Keywords:

Factor B-IN-51644670-23-4Complement SystemCFBinflammationdiabetic nephropathymitochondriadb/db micediabetes mellituInhibitorinhibitorinhibit

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Nombre del producto:
Factor B-IN-5
Cat. No.:
HY-174913
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