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Cat. No.: HY-168958

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Ferroptosis-IN-18

Ferroptosis-IN-18 (51), a promethazine derivative, shows strong anti-ferroptosis and anti-oxidant properties. Ferroptosis-IN-18 (51) can be used in the research for intracerebral hemorrhage (ICH).

For research use only. We do not sell to patients.

CAS No.: 2247525-20-6
Formula: C₂₅H₂₇N₃S
Molecular Weight:401.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ferroptosis-IN-18 Chemical Structure

CAS No.: 2247525-20-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

GPX4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
Bel-7402	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
BJ	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
BXPC-3	EC₅₀	2.925 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human BXPC-3 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human BXPC-3 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
Calu-1	EC₅₀	1.879 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human Calu-1 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human Calu-1 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
CHL-1	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human CHL-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human CHL-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
DU-145	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HaCaT	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HEK-293T	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HT-1080	EC₅₀	0.0005 μM Compound: 51	Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
HT-1080	EC₅₀	0.5 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
Huh-7	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HUVEC	IC₅₀	>10 μM Compound: 51	Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
K562	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
L02	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
Malme-3M	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human Malme-3M cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Malme-3M cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
MDA-MB-231	EC₅₀	0.424 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
MDA-MB-231	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
MDA-MB-435	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
NCI-H1975	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
NCI-H23	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
PC-9	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
SK-OV-3	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
U-251	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human U-251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U-251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
U-87MG ATCC	IC₅₀	>10 μM Compound: 51	Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]

In Vitro

Ferroptosis-IN-18 (51) increases cell viability and GPX4 levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2247525-20-6
Molecular Weight 401.57
Formula C₂₅H₂₇N₃S
SMILES

CC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)C4=CC=C(N5CCN(C)CC5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bing-Qiao Wang, et al. A novel ferroptosis inhibitor phenothiazine derivative reduces cell death and alleviates neurological impairments after cerebral hemorrhage. Neuropharmacology. 2025 Jun 15:271:110399. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Ferroptosis-IN-18

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Ferroptosis-IN-18 Related Classifications

HY-168958 Related Classifications