Ferroptosis-IN-18

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Ferroptosis-IN-18 (51), a promethazine derivative, shows strong anti-ferroptosis and anti-oxidant properties. Ferroptosis-IN-18 (51) can be used in the research for intracerebral hemorrhage (ICH).

For research use only. We do not sell to patients.

Ferroptosis-IN-18 Chemical Structure

CAS No. : 2247525-20-6

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GPX1 GPX4

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
BJ	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
BXPC-3	EC₅₀	2.925 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human BXPC-3 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human BXPC-3 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
Bel-7402	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
CHL-1	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human CHL-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human CHL-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
Calu-1	EC₅₀	1.879 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human Calu-1 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human Calu-1 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
DU-145	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HEK-293T	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HT-1080	EC₅₀	0.0005 μM Compound: 51	Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
HUVEC	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
HaCaT	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
Huh-7	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
K562	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
L02	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
MDA-MB-231	EC₅₀	0.424 nM Compound: 51	Inhibition of erastin-induced ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay Inhibition of erastin-induced ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay	[PMID: 33065375]
MDA-MB-231	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
MDA-MB-435	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
Malme-3M	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human Malme-3M cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Malme-3M cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
NCI-H1975	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
NCI-H23	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
PC-9	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
SK-OV-3	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
U-251	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human U-251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U-251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]
U-87MG ATCC	IC₅₀	> 10 μM Compound: 51	Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33065375]

In Vitro

Ferroptosis-IN-18 (51) increases cell viability and GPX4 levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

401.57

Formula

C₂₅H₂₇N₃S

CAS No.

2247525-20-6

SMILES

CC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)C4=CC=C(N5CCN(C)CC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bing-Qiao Wang, et al. A novel ferroptosis inhibitor phenothiazine derivative reduces cell death and alleviates neurological impairments after cerebral hemorrhage. Neuropharmacology. 2025 Jun 15:271:110399. [Content Brief]