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Cat. No.: HY-149719

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Ferroptosis-IN-4

Ferroptosis-IN-4 (compound 6k) is a ferroptosis inhibitor with EC₅₀ value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction.

For research use only. We do not sell to patients.

CAS No.: 2798922-35-5
Formula: C₁₇H₂₄ClN₃O₂
Molecular Weight:337.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ferroptosis-IN-4 Chemical Structure

CAS No.: 2798922-35-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HK-2	CC₅₀	>100 μM Compound: 6k	Cytotoxicity against human HK-2 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay Cytotoxicity against human HK-2 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay	[PMID: 37976703]
HK-2	EC₅₀	20 μM Compound: 6k	Inhibition of RSL-3 induced ferroptosis in human HK-2 cells incubated for 48 hrs in presence of FAC Inhibition of RSL-3 induced ferroptosis in human HK-2 cells incubated for 48 hrs in presence of FAC	[PMID: 37976703]

Chemical Information

CAS No. 2798922-35-5
Molecular Weight 337.84
Formula C₁₇H₂₄ClN₃O₂
SMILES

CN(CCN(C)C)C1=CC=C(N2C(C)=C(O)C(C=C2)=O)C=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jie Cen, et al. Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury. Eur J Med Chem. 2023. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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