Fiduxosin hydrochloride
Fiduxosin hydrochloride (ABT 980) is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively.
For research use only. We do not sell to patients.
- CAS No.: 208992-74-9
- Formula: C30H30ClN5O4S
- Molecular Weight:592.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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α1A-adrenergic receptor 0.16 nM (IC50) |
α1B-adrenergic receptor 24.9 nM (IC50) |
α1D-adrenergic receptor 0.92 nM (IC50) |
Chemical Information
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CAS No. 208992-74-9
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Molecular Weight 592.11
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Formula C30H30ClN5O4S
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SMILES
O=C1C2=C(NC(N1CCCCN3C[C@]4([H])[C@](COC5=CC=CC(OC)=C54)([H])C3)=O)C6=NC(C7=CC=CC=C7)=CN=C6S2.Cl
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Synonyms
ABT 980
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hancock AA, et al. Preclinical pharmacology of fiduxosin, a novel alpha(1)-adrenoceptor antagonist with uroselective properties. J Pharmacol Exp Ther. 2002 Feb;300(2):478-86. [Content Brief]
[2]. Brune ME, et al. Effect of fiduxosin, an antagonist selective for alpha(1A)- and alpha(1D)-adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther. 2002 Feb;300(2):487-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fiduxosin hydrochloride Related Classifications
HY-U00399A Related Classifications
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