2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3-IN-20

FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor with IC50 values of 1 and 4 nM for FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-20 has anti-proliferation efficacy in FLT3-ITD-positive AML cell lines MV4-11 and MOLM-13 (7 and 9 nM, respectively) and the MOLM-13 variant (4 nM) with the FLT3-ITD-D835Y mutation. FLT3-IN-20 can be used in research of cancer.

For research use only. We do not sell to patients.

FLT3-IN-20

FLT3-IN-20 Chemical Structure

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FLT3-IN-20 Related Antibodies

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Description

FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor with IC50 values of 1 and 4 nM for FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-20 has anti-proliferation efficacy in FLT3-ITD-positive AML cell lines MV4-11 and MOLM-13 (7 and 9 nM, respectively) and the MOLM-13 variant (4 nM) with the FLT3-ITD-D835Y mutation. FLT3-IN-20 can be used in research of cancer[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM GI50
1.768 μM
Compound: 34f
Antiproliferative activity against FLT3-independent human CEM cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against FLT3-independent human CEM cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
K562 GI50
1.525 μM
Compound: 34f
Antiproliferative activity against FLT3-independent human K562 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against FLT3-independent human K562 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
Kasumi 1 GI50
0.188 μM
Compound: 34f
Antiproliferative activity against human Kasumi 1 cells harboring KIT N822K mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against human Kasumi 1 cells harboring KIT N822K mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
ML-2 GI50
3.03 μM
Compound: 34f
Antiproliferative activity against FLT3-independent human ML-2 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against FLT3-independent human ML-2 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
MOLM-13 GI50
0.004 μM
Compound: 34f
Antiproliferative activity against drug-resistant human MOLM-13 cells expressing FLT3-ITD-D835Y mutant assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis
Antiproliferative activity against drug-resistant human MOLM-13 cells expressing FLT3-ITD-D835Y mutant assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis
[PMID: 37535845]
MOLM-13 GI50
0.009 μM
Compound: 34f
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
MOLM-13 GI50
0.01 μM
Compound: 34f
Antiproliferative activity against FLT3-dependent human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis
Antiproliferative activity against FLT3-dependent human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis
[PMID: 37535845]
MV4-11 GI50
0.007 μM
Compound: 34f
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
NOMO-1 GI50
4.275 μM
Compound: 34f
Antiproliferative activity against FLT3-independent human NOMO-1 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against FLT3-independent human NOMO-1 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
SEM GI50
0.14 μM
Compound: 34f
Antiproliferative activity against human SEM cells overexpressing wild type FLT3 assessed as cell growth inhibition by resorufin dye based fluorescence analysis
Antiproliferative activity against human SEM cells overexpressing wild type FLT3 assessed as cell growth inhibition by resorufin dye based fluorescence analysis
[PMID: 37535845]
Molecular Weight

531.67

Formula

C28H33N7O2S
SMILES

O=S(C1=CC=C(NC2=CC(N[C@@H]3CC[C@@H](N)CC3)=NN4C2=NC=C4C5=CC=CC=C5)C=C1)(N6CCCC6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLT3-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-20FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3-D835YFLT3-ITDanti-proliferationcancerInhibitorinhibitorinhibit

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