Dnm2 - dynamin 2 Gene

Also Known as DYIIAAB

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25751

Summary

Enables several functions, including D2 Dopamine Receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of transport; regulation of plasma membrane bounded cell projection assembly; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and ruffle membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with growth cone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (Dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]

Dnm2 Products (1)

mRNA Protein Name
NM_013199.2 NP_037331.1 dynamin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D2 dopamine receptor binding IPI
IPI: Inferred from physical interaction
14709338 RGD
enables GTPase activity IDA
IDA: Inferred from direct assay
16325581 RGD
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
19122684 RGD
enables WW domain binding IPI
IPI: Inferred from physical interaction
23994472 RGD
enables nitric-oxide synthase binding IDA
IDA: Inferred from direct assay
21490139 RGD
enables phosphatidylinositol 3-kinase regulatory subunit binding IDA
IDA: Inferred from direct assay
12205083 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11583995 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15007081 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
20802490 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17257598 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor internalization IMP
IMP: Inferred from mutant phenotype
14709338 RGD
involved in Golgi to plasma membrane transport IMP
IMP: Inferred from mutant phenotype
20231454 RGD
involved in actin filament bundle organization IMP
IMP: Inferred from mutant phenotype
19605363 RGD
involved in cellular response to X-ray IEP
IEP: Inferred from expression pattern
15994918 RGD
involved in cellular response to carbon monoxide IEP
IEP: Inferred from expression pattern
25100282 RGD
involved in cellular response to dopamine IDA
IDA: Inferred from direct assay
12205083 RGD
involved in cellular response to nitric oxide IEP
IEP: Inferred from expression pattern
25100282 RGD
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
15048127 RGD
involved in macropinocytosis IMP
IMP: Inferred from mutant phenotype
18003703 RGD
involved in membrane tubulation IMP
IMP: Inferred from mutant phenotype
35620056 RGD
involved in negative regulation of non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
23994472 RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25100282 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
21210813 RGD
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity IMP
IMP: Inferred from mutant phenotype
12205083 RGD
involved in positive regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
11925437 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
18435821 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
14617821 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16973909 RGD
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
12802072 RGD
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
14617821 RGD
involved in postsynaptic endocytosis EXP
EXP: Inferred from Experiment
31597090 RGD
involved in postsynaptic endocytosis IDA
IDA: Inferred from direct assay
31597090 RGD
involved in postsynaptic endocytosis IMP
IMP: Inferred from mutant phenotype
31597090 RGD
involved in protein polymerization IMP
IMP: Inferred from mutant phenotype
35620056 RGD
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
11925437 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
19995918 RGD
involved in regulation of Golgi organization IMP
IMP: Inferred from mutant phenotype
20231454 RGD
involved in regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
14617821 RGD
involved in regulation of axon extension IMP
IMP: Inferred from mutant phenotype
21210813 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
19562697 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
22666495 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
12199526 RGD
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
35620056 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
15821732 RGD
located in cell junction IDA
IDA: Inferred from direct assay
21210813 RGD
located in centrosome IDA
IDA: Inferred from direct assay
15048127 RGD
located in clathrin-coated endocytic vesicle IDA
IDA: Inferred from direct assay
11925437 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
9725914 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
9438853 RGD
located in endosome IDA
IDA: Inferred from direct assay
12802072 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
31597090 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11583995 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11583995 RGD
located in growth cone IDA
IDA: Inferred from direct assay
21210813 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
9725914 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
11583995 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15126636 RGD
located in phagocytic cup IDA
IDA: Inferred from direct assay
12802072 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
11583995 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
11583995 RGD
is active in postsynaptic density, intracellular component IMP
IMP: Inferred from mutant phenotype
11583995 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
35072626 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17257598 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
9725914 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12802072 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynamin-2

Dnm2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Dnm2 P39052 SH3BP4 Homo sapiens Q9P0V3
SPR
16325581
Cross
Dnm2 P39052 SH3BP4 Homo sapiens Q9P0V3
Pull Down
16325581
Cross
Dnm2 P39052 SH3KBP1 Homo sapiens Q96B97
Pull Down
20711168
Cross
Dnm2 P39052 SORBS1 Homo sapiens Q9BX66
Pull Down
19116150
Intra
Dnm2 P39052 Shank1 Rattus norvegicus Q9WV48
Anti Tag CoIP
11583995
Intra
Dnm2 P39052 Shank1 Rattus norvegicus Q9WV48
Anti Bait CoIP
11583995
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132583A IONIS-DNM2-2.5Rx sodium 97.46% Unkown
HY-RS03905 DNM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132583 IONIS-DNM2-2.5Rx / Unkown
HY-132583D IONIS-DNM2-2.5Rx sodium scrambled negative control / Unkown
HY-132583E FAM labled IONIS-DNM2-2.5Rx sodium / Unkown
HY-132583H Cy3 labled IONIS-DNM2-2.5Rx sodium / Unkown
HY-RS22143 Dnm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28664 Dnm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnm2 NCBI NCBI:1785