Minimycin
Minimycin (Oxazinomycin) is a nucleoside antibiotic with a broad-spectrum antibacterial activity. Minimycin has inhibitory effect on mouse Ehrlich ascites carcinoma, ascites type and solid type sarcoma-180.
For research use only. We do not sell to patients.
- CAS No.: 32388-21-9
- Formula: C9H11NO7
- Molecular Weight:245.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
5.0 x 10-7M
Compound: oxazinomycin
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Antitumor activity against HeLa cells
Antitumor activity against HeLa cells
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[PMID: 6276541] |
| HeLa | IC50 |
5.00E-07 M
Compound: oxazinomycin
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Antitumor activity against HeLa cells
Antitumor activity against HeLa cells
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[PMID: 6276541] |
| L1210 | IC50 |
3.0 x 10-7M
Compound: oxazinomycin
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Antitumor activity against L1210 cells
Antitumor activity against L1210 cells
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[PMID: 6276541] |
| L1210 | IC50 |
3.00E-07 M
Compound: oxazinomycin
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Antitumor activity against L1210 cells
Antitumor activity against L1210 cells
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[PMID: 6276541] |
Chemical Information
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CAS No. 32388-21-9
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Molecular Weight 245.19
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Formula C9H11NO7
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SMILES
O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C2=COC(NC2=O)=O
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Synonyms
Oxazinomycin
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Structure Classification
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Initial Source
Streptomyces hygroscopicus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Minimycin Related Classifications
HY-128514 Related Classifications
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