Fudosteine
Based on 2 publication(s) in Google Scholar
Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 13189-98-5
- Formula: C6H13NO3S
- Molecular Weight:179.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fudosteine
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Biological Activity
Description
In Vitro
Fudosteine (50, 100, 200 mg/kg) decreases the LPS-induced p-ERK1/2 and p-p38 MAPK levels in the rat lungs. The TNF-α-induced increase in MUC5AC mRNA expression is inhibited by pretreatment with 1 mM Fudosteine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 13189-98-5
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Appearance Solid
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Molecular Weight 179.24
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Formula C6H13NO3S
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Color White to off-white
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SMILES
N[C@@H](CSCCCO)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (557.91 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (278.96 mM); Clear solution; Need ultrasonic
Protocols
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RT-PCR
Reverse transcription technology uses RNA as a template to synthesize DNA. RT-PCR is simple, specific and sensitive, and can be used to detect gene expression levels and expression differences in cells; detect RNA virus content; clone cDNA sequences of specific genes.
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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Real Time qPCR (Q-PCR)
Real-time quantitative PCR (qPCR) quantifies an amplifiable nucleic-acid target by monitoring fluorescence during PCR cycling rather than measuring product only after amplification. The increase in fluorescence tracks accumulation of PCR product, and the quantification cycle (Cq; historically also Ct/CP) is related to the initial amount of target: samples containing more starting target generally reach the defined fluorescence threshold in fewer cycles.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.5791 mL | 27.8956 mL | 55.7911 mL | 139.4778 mL |
| 5 mM | 1.1158 mL | 5.5791 mL | 11.1582 mL | 27.8956 mL | |
| 10 mM | 0.5579 mL | 2.7896 mL | 5.5791 mL | 13.9478 mL | |
| 15 mM | 0.3719 mL | 1.8597 mL | 3.7194 mL | 9.2985 mL | |
| 20 mM | 0.2790 mL | 1.3948 mL | 2.7896 mL | 6.9739 mL | |
| 25 mM | 0.2232 mL | 1.1158 mL | 2.2316 mL | 5.5791 mL | |
| 30 mM | 0.1860 mL | 0.9299 mL | 1.8597 mL | 4.6493 mL | |
| 40 mM | 0.1395 mL | 0.6974 mL | 1.3948 mL | 3.4869 mL | |
| 50 mM | 0.1116 mL | 0.5579 mL | 1.1158 mL | 2.7896 mL | |
| 60 mM | 0.0930 mL | 0.4649 mL | 0.9299 mL | 2.3246 mL | |
| 80 mM | 0.0697 mL | 0.3487 mL | 0.6974 mL | 1.7435 mL | |
| 100 mM | 0.0558 mL | 0.2790 mL | 0.5579 mL | 1.3948 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fudosteine Related Classifications
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